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Printable Handouts
Navigable Slide Index
- Introduction
- Ethnic variation in diabetes
- Top 10 countries for type 1 and type 2 diabetes
- Global variation in incidence of T1DM in children
- DIAMOND project
- SEARCH study
- Why does ethnicity influence risk of type 1 diabetes?
- Diabetes: a global emergency
- DM prevalence in Qatar and Australia
- Diabetes around the world (1)
- Economic development and prevalence of T2DM
- Diabetes around the world (2)
- NCD RisC estimates
- Rural diabetes prevalence in low- and middle-income countries
- Progressive increase in prevalence of diabetes over 20 yrs - Mauritius
- Diabetes prevalence in India 1955-2005
- Trends in diabetes prevalence in Asia
- Type 2 diabetes prevalence in the United States according to ethnicity
- Type 2 diabetes prevalence in the United States according to Asian sub-group
- What drives the high risk of T2DM in South Asians (1)?
- What drives the high risk of T2DM in South Asians (2)?
- Type 2 diabetes prevalence in the United States
- High prevalence of T2DM in indigenous Australians
- Ethnicity and complications of diabetes
- Huge burden of end stage kidney disease in Indigenous populations
- Trends in all cause mortality among people with diabetes over time
- Complication incidence by region in the ADVANCE cohort
- Percentage of hospital days due to diabetic complications in the ADVANCE cohort
- Incidence of MI, stroke and ESKD in the USA and Hong Kong
- Ethnic differences in prevalence of diabetic complications – US veterans
- Prevalence of diabetic complications – UK population
- Does diabetes confer the same IHD risk in different ethnic groups
- CVD mortality risk associated with DM appears to be greater in South Asian populations
- Adjusted risks of having diabetic kidney disease in patients with T2DM in California
- Diabetic kidney disease* in patients with T2DM in Singapore
- Percentage of ESKD due to diabetes
- Microalbuminuria and BP among T2DM patients in 33 countries
- Proportion of patients with T2D with chronic kidney disease and albuminuria in Asia
- Target achievement and management in seven regions/areas in Asia (JADE registry)
- Cost of treating diabetic foot ulcers in five different countries
- Number of months of average income to cover patient co-payment
- Summary
Topics Covered
- Different type of diabetes exhibits diverse ethnic patterns of diabetes
- T1D diabetes in people of European origin
- T2D diabetes in Non-European and indigenous populations
- High rates of T1D and T2D among some middle eastern countries
- T2D in South Asian populations caused by increased visceral fat and poorer beta cell function
- Association of early onset T2D with high risk of the disease
- Ethnicity and complication rates
- Personal cost burden of complications in lower and middle income countries
Links
Categories:
Therapeutic Areas:
Talk Citation
Shaw, J. (2020, April 29). Ethnic variation in the susceptibility to diabetes [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/QBDH7030.Export Citation (RIS)
Publication History
Financial Disclosures
- Professor Jonathan Shaw has received funding for consultancies and lectures from:Astra Zeneca; Sanofi; Novo Nordisk; MSD; Eli Lilly; Abbott; Mylan; Boehringer Ingelheim
A selection of talks on Genetics & Epigenetics
Transcript
Please wait while the transcript is being prepared...
0:00
Hello, I'm Professor Jonathan Shaw.
I'm from the Baker Heart and Diabetes Institute in Melbourne, Australia,
and I'm going to talk today about
the variation due to ethnicity in the susceptibility to diabetes.
0:15
So there is significant ethnic variation,
in the manifestations of diabetes,
and we see marked differences across the world in the susceptibility to diabetes.
Interestingly, the pattern of this is quite
different for type 1 diabetes than it is for type 2.
In other words, those ethnicities in
those parts of the world that are at high risk for type 1,
are on the lower end of the risk spectrum for type 2 diabetes.
As we'll see, there are a number of factors that may underlie ethnic variation.
Although the reality is that this is not adequately understood,
the various factors include genes,
include variations in diet,
in the physical environments,
and also recognized in recent years,
the impact of gestational exposure,
particularly to hyperglycemia during pregnancy.
1:10
So if we start by just comparing
the top 10 ranked countries for type 1 and type 2 diabetes,
you see on the left the countries with
the highest incidence of type 1 diabetes in children and adolescents,
and incidence, in other words,
the rate at which new cases occur is the most commonly used metric for type 1 diabetes,
and on the right we have
the top 10 ranked countries for the prevalence of type 2 diabetes.
In other words, the proportion of the population in
this case are adults who have type 2 diabetes,
because that is the most commonly used metric of burden of type 2 diabetes.
Just running your eye down the countries,
you see that for type 1 diabetes,
this is mainly dominated by European countries.
We see Finland at the top,
we then see Sweden and Norway,
United Kingdom, Ireland, and Denmark towards the bottom end.
Not only are these European countries but they are countries
predominantly from Northern and Western Europe.
That is quite different to the profile of
the countries where the prevalence of type 2 diabetes is the highest.
We see several small Pacific Islands at the top there, Marshall Islands,
Kiribati, followed by Mauritius in
the Indian Ocean and Solomon Islands again in the Pacific.
So what do we have here is we have
predominantly Northern and Northwestern European countries for
type 1 diabetes and predominantly Pacific Islands for type 2 diabetes,
but somewhat surprisingly from a number of studies in the last 10 or 20 years,
we are also now starting to see
Middle Eastern countries showing high risk for type 1 diabetes.