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Printable Handouts
Navigable Slide Index
- Introduction
- [Ca]c oscillations
- Agonist specificity
- Routes of Ca movement
- How is [Ca]c elevated?
- How is [Ca]c decreased?
- Plasma membrane Ca efflux is the least studied
- Ca efflux across the plasma membrane
- Ca efflux across the plasma membrane: NCX
- Ca efflux across the plasma membrane: PMCA
- Ca efflux from rat hepatocytes
- Carboxyeosin and mini-glucagon
- Carboxyeosin and Phe-induced oscillations
- Carboxyeosin and ATP-induced oscillations
- Mini-glucagon and Phe-induced oscillations
- Mini-glucagon and ATP-induced oscillations
- PMCA inhibitors increase oscillation frequency
- Removal of extracellular Ca and oscillations
- Inhibition of plasma membrane Ca efflux
- [Ca]c oscillations in smooth muscle cells
- Decrease of plasma membrane Ca influx
- Net plasma membrane Ca flux
- Mini-glucagon is agonist for hepatocytes
- Atrial natriuretic peptide (ANP)
- ANP acts on the GC-A receptor
- ANP stimulates cGMP production
- ANP and 8-Br-cGMP stimulate Ca efflux
- ANP partially inhibits basal cation influx
- Neither ANP nor 8-Br-cGMP elevate [Ca]c
- ANP and Phe-induced oscilations
- ANP and ATP-induced oscilations
- 8-Br-cGMP and Phe-induced oscilations
- Major observation regarding ANP
- Plasma membrane Ca flux and oscillations
- [Ca]c waves
- The model
- Mini-glucagon inhibits Ca efflux
- Mini-glucagon increases Ca oscillation frequency
- ANP stimulates Ca efflux
- ANP attenuates oscillations
- Ca efflux modulators
- Brain natriuretic peptide
- CD22
- Ca efflux modulators and downstream processes
- Frequency-modulation of [Ca]i oscillations
- Conclusion
- References
- Acknowledgements
Topics Covered
- Introduction to [Calcium]c oscillations
- Involvement of Calcium fluxes in [Calcium]c oscillations
- Plasma membrane Calcium efflux
- Impact of Calcium efflux inhibition on [Calcium]c oscillations
- Mini-glucagon as a physiological Calcium efflux inhibitor
- Atrial natriuretic peptide as a physiological Calcium efflux stimulator
- A hypothetical mechanism for plasma membrane Calcium flux as a determinant of [Calcium]c oscillation frequency
- 'Calcium efflux modulators': a class of physiological agonists?
Talk Citation
Green, A. (2007, October 1). Ca2+ efflux and Ca2+ signals [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2025, from https://doi.org/10.69645/QWZG1902.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Anne Green has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.