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1. Introduction
2. [Ca]c oscillations
3. Agonist specificity
4. Routes of Ca movement
5. How is [Ca]c elevated?
6. How is [Ca]c decreased?
7. Plasma membrane Ca efflux is the least studied
8. Ca efflux across the plasma membrane
9. Ca efflux across the plasma membrane: NCX
10. Ca efflux across the plasma membrane: PMCA
11. Ca efflux from rat hepatocytes
12. Carboxyeosin and mini-glucagon
13. Carboxyeosin and Phe-induced oscillations
14. Carboxyeosin and ATP-induced oscillations
15. Mini-glucagon and Phe-induced oscillations
16. Mini-glucagon and ATP-induced oscillations
17. PMCA inhibitors increase oscillation frequency
18. Removal of extracellular Ca and oscillations
19. Inhibition of plasma membrane Ca efflux
20. [Ca]c oscillations in smooth muscle cells
21. Decrease of plasma membrane Ca influx
22. Net plasma membrane Ca flux
23. Mini-glucagon is agonist for hepatocytes
24. Atrial natriuretic peptide (ANP)
25. ANP acts on the GC-A receptor
26. ANP stimulates cGMP production
27. ANP and 8-Br-cGMP stimulate Ca efflux
28. ANP partially inhibits basal cation influx
29. Neither ANP nor 8-Br-cGMP elevate [Ca]c
30. ANP and Phe-induced oscilations
31. ANP and ATP-induced oscilations
32. 8-Br-cGMP and Phe-induced oscilations
33. Major observation regarding ANP
34. Plasma membrane Ca flux and oscillations
35. [Ca]c waves
36. The model
37. Mini-glucagon inhibits Ca efflux
38. Mini-glucagon increases Ca oscillation frequency
39. ANP stimulates Ca efflux
40. ANP attenuates oscillations
41. Ca efflux modulators
42. Brain natriuretic peptide
43. CD22
44. Ca efflux modulators and downstream processes
45. Frequency-modulation of [Ca]i oscillations
46. Conclusion
47. References
48. Acknowledgements

Topics Covered

• Introduction to [Calcium]c oscillations
• Involvement of Calcium fluxes in [Calcium]c oscillations
• Plasma membrane Calcium efflux
• Impact of Calcium efflux inhibition on [Calcium]c oscillations
• Mini-glucagon as a physiological Calcium efflux inhibitor
• Atrial natriuretic peptide as a physiological Calcium efflux stimulator
• A hypothetical mechanism for plasma membrane Calcium flux as a determinant of [Calcium]c oscillation frequency
• 'Calcium efflux modulators': a class of physiological agonists?

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Dr. Anne Green has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.