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1. Introduction
2. History
3. History - calcium is essential to sustain heartbeat
4. Calcium and cytotoxicity
5. Arsenazo III
6. Calcium accumulation and cell death
7. Effect of oxidative stress on calcium storage
8. Effect of oxidative stress on calcium extrusion
9. Downstream effectors of calcium toxicity
10. The calcium and thiol hypothesis of cell death
11. The inositolphosphate pathway and calcium
12. Calcium signaling as target of chemical toxicity
13. Ca2+ is involved in different cell death paradigms
14. The discovery of regulated nuclear Ca2+ transport
15. Ca2+ - activated degradative processes
16. Intracellular Ca2+ distribution in living cells
17. Ca2+ and phosphatidylserines exposure
18. Plasma membrane calcium pumps (PMCAs)
19. Cleavage of PMCA2 in apoptosis
20. hPMCA4 is cleaved and inactivated by caspases
21. Mutation of caspase-3 cleavage site on hPMCA4
22. hPMCA4 localization and its loss on apopatosis
23. PMCA4 transfection restores calcium handling
24. PMCA mutants protect against cell death
25. Conserved death mechanisms
26. Ca2+ deregulation and neuronal death
27. Ca2+ deregulation in excitotoxic death
28. NCX3 cleavage by calpains and Ca2+ overload
29. NCX mutants and Ca2+ overload
30. NCX3 siRNA amplifies death signals
31. Effect of non-cleavable NCX on excitotoxicity
32. Common features in cell death pathways
33. Conclusion: role of calcium in cell death

Topics Covered

• Calcium and cytotoxicity
• Indicator dyes for calcium detection
• Alteration of thiol and calcium homeostasis causes cell death
• Oxidative stress and thiol modification impair calcium storage and extrusion
• Calcium ATPase
• The calcium and thiol hypothesis of cell death
• Calcium as a second messenger
• Calcium is involved in different cell death paradigms
• Nuclear calcium transport
• Intracellular calcium distribution
• PMCAs: vital membrane calcium transporters
• PMCAs are degraded during cell death
• Non-degradable PMCAs protect against cell death
• Mechanisms of calcium deregulation during cell death
• NCX3 and calpains in calcium maintenance
• Prevention of excitotoxicity via calcium management

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on February 25, 2021

Financial Disclosures

• Prof. Pierluigi Nicotera has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.