Registration for a live webinar on 'Precision medicine treatment for anticancer drug resistance' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Introduction to Calcium Signaling
-
1. Introduction to cellular calcium signaling
- Dr. Martin Bootman
-
2. Monitoring Ca2+ concentration in living cells
- Dr. Marisa Brini
-
3. Cell boundary theorem
- Prof. Eduardo Ríos
- Calcium Influx
-
4. Arachidonic acid and store-independent Ca2+ entry
- Dr. Luca Munaron
-
5. Voltage-dependent calcium channels
- Prof. Annette Dolphin
-
7. Intracellular Ca2+ signaling: calcium influx
- Prof. Anant Parekh
-
8. Molecular identification of the CRAC channel
- Prof. Michael Cahalan
- Calcium Release
-
10. The InsP3 receptor calcium release channel
- Prof. J. Kevin Foskett
-
11. Molecular biology of ryanodine receptors: an overview
- Dr. Christopher George
- Prof. F. Anthony Lai
-
12. cADPR and NAADP: messengers for calcium signalling
- Prof. Antony Galione
-
13. Ryanodine receptors and cardiac function
- Prof. David Eisner
- Calcium Efflux and Sequestration
-
14. Sodium-calcium exchange
- Prof. John Reeves
- Organelle Calcium
-
15. Regulation and role of mitochondrial Ca2+ homeostasis
- Prof. Rosario Rizzuto
-
16. Peroxisomes and Golgi apparatus as players in Ca2+ homeostasis
- Dr. Paola Pizzo
- Dr. Alex Costa
-
17. Ca2+ dynamics between mitochondria and the endoplasmic reticulum
- Dr. Wolfgang Graier
-
18. Nuclear calcium signaling
- Dr. Oleg Gerasimenko
- Dr. Julia Gerasimenko
- Spatiotemporal Calcium Signals
-
19. Regulation of intracellular calcium signaling, localized signals and oscillations
- Prof. Barbara Ehrlich
- Calcium Effectors
-
24. Calcium-regulated adenylyl cyclases and cyclic AMP compartmentalization
- Prof. Dermot Cooper
-
25. Calcium and transcription-coupling
- Dr. Karen Lounsbury
-
26. Cellular calcium (Ca2+) buffers
- Prof. Dr. Beat Schwaller
-
27. Extracellular calcium signaling
- Dr. Aldebaran M. Hofer
-
28. Ca2+, fertilization and egg activation
- Prof. Karl Swann
-
29. Calcium regulation of transcription in plants
- Prof. Hillel Fromm
-
30. Mechanisms regulating STIM expression and function in Ca2+ signaling
- Dr. Jonathan Soboloff
-
31. Dynamic signal encoding in the S. cerevisiae calcium response
- Dr. Chiraj Dalal
- Calcium and Disease
-
32. Polycystins, calcium signaling and pathogenesis of polycystic kidney disease
- Prof. Laura del Senno
-
33. Ca2+ alterations in familial Alzheimer's disease (FAD)
- Dr. Paola Pizzo
-
34. Pancreatitis and calcium signaling
- Prof. Ole Petersen
-
35. Mechanism-based therapies for heart failure and cardiac arrhythmias
- Prof. Andrew Marks
-
36. Genetic defects and calcium
- Prof. Tullio Pozzan
- Archived Lectures *These may not cover the latest advances in the field
-
37. Calcium, calmodulin and calcineurin
- Prof. Stephen Bolsover
-
38. Calcium flickers steer cell migration
- Prof. Heping Cheng
-
39. Automated Ca2+ imaging of chemosensory neurones in C.elegans
- Dr. Nikos Chronis
-
40. Ca2+ and the regulation of small GTPases
- Prof. Peter Cullen
-
41. Genetically encoded Ca2+ indicators: molecular scale measurements in mammals in vivo
- Dr. Michael I. Kotlikoff
-
42. Capacitative (store-operated) calcium entry
- Dr. Jim Putney
-
43. The molecular biology of the inositol trisphosphate receptor
- Dr. Randen Patterson
-
44. Coordinated Ca2+ release from intracellular Ca2+ stores
- Prof. Ole Petersen
-
45. The plasma membrane calcium pump: biochemistry, physiology and molecular pathology
- Prof. Ernesto Carafoli
-
46. The calcium saga: a matter of life and death
- Prof. Pierluigi Nicotera
-
47. Ca2+ efflux and Ca2+ signals
- Dr. Anne Green
-
50. Modeling Ca2+ signals
- Dr. David Friel
Printable Handouts
Navigable Slide Index
- Introduction
- Calcium is an ubiquitous messenger
- Spatial control of calcium
- Calcium-reporting dyes
- Basic mechanisms of calcium regulation
- Why have internal calcium stores and release?
- Some organelles that serve as calcium stores
- Ca mobilization by hormones/ neurotransmitters
- Calcium mobilizing messengers
- Intracellular signaling by IP3
- Structures of calcium mobilizing messengers
- Multiple Ca release mechanisms
- cADPR activity was discovered in sea urchin eggs
- Studying Ca release in cell-free systems
- Ca release in urchin egg homogenates
- Role of cADPR in calcium signaling
- Second messenger roles for cADPR
- cADPR/NAADP synthesis, analogues and drugs
- Synthesis of cADPR and analogues
- Caged cADPR photolysis induces Ca waves
- Caged Ca photolysis evokes local Ca rise
- Potentiation of CICR by cADPR
- Ryanodine receptors: function
- Ryanodine receptors: imaging elementary events
- Photolysis released cADPR and Ca transients
- cADPR antagonist abolishes Ca waves
- cADPR increases the frequency of Ca sparks
- Mechanism of enhanced Ca release by cADPR
- Isoprenaline-evoked increases in cADPR levels
- Pharmacology of cADPR increases
- Role of cADPR in cardiac E-C coupling
- Summary of cADPR activity
- cADPR in Ca signaling
- What is NAADP
- Photolysing caged NAADP results in a Ca wave
- Spatial sensitivity to low [NAADP]
- Effect of CICR channels inhibition
- NAADP: spatial/ temporal aspects of Ca signals
- NAADP stores are separate from the ER
- Stratification of sea urchin eggs
- GPN rupture lysosomes
- Lysotracker
- GPN ruptures lysosomes and releases Ca
- NAADP is an initiator: Ca-induced Ca release
- NAADP releases Ca from lysosomal stores
- Organelle marker enzymes
- Receptor distribution
- Ca uptake into NAADP-sensitive stores
- NAADP: special channel or special regulation?
- Inhibition of NAADP-induced Ca release
- NAADP-induced calcium release
- NAADP-induced Ca release amplification by RyR
- Bafilomycin inhibits NAADP-induced Ca release
- Interactions between NAADP and CICR channels
- Auto-inactivation of NAADP-induced Ca release
- Specificity of receptor-mediated NAADP signaling
- NAADP triggers global Ca signals
- CCK-evoked calcium spiking blocked by GPN
- CCK-evoked calcium spiking blocked: bafilomycin
- Selectivity in GPN blockage
- Radio-receptor assay for NAADP levels
- CCK-induced changes in NAADP / cADPR levels
- NAADP: trigger hypothesis
- Receptor specificity in pancreatic acinar cells
- ARC can synthesize cADPR and NAADP
- NAADP changes in CD38-/- mouse
- NAADPR is easily solubilized as a native protein
- Affinity purification of the NAADP receptor
- NAADP binding proteins
- Summary
Topics Covered
- Calcium signaling mechanisms
- Calcium stores and calcium mobilization
- Intracellular calcium release channels
- cADPR as an intracellular messenger
- Ryanodine receptors
- Cardiac excitation
- Coupling
- NAADP
- Acidic calcium store
- Smooth muscle cell calcium signaling
- Calcium spiking
- NAADP receptors
Talk Citation
Galione, A. (2007, October 1). cADPR and NAADP: messengers for calcium signalling [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 12, 2024, from https://doi.org/10.69645/MZOM2005.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Antony Galione has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.