Activation of the IP3-receptor (IP3R), a major endoplasmic Calcium release channel in many cells, is activated by the second messenger inositol 1,4,5-trisphosphate (IP3)
The IP3R is unique in that it can integrate signals from numerous cellular pathways via a myriad of inputs which include nucleotide binding, phosphorylation, Calcium binding and protein-protein interactions
A diverse range of cellular functions are modulated by the IP3R including contraction/excitation, secretion, gene expression, cell cycle, apoptosis and cellular growth
The nodal properties of the IP3R and the mechanisms by which this occurs
Patterson, R. (2007, October 1). The molecular biology of the inositol trisphosphate receptor [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 23, 2023, from https://hstalks.com/bs/404/.
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Published on October 1, 2007
Archived on February 25, 2021
Dr. Randen Patterson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.