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Printable Handouts
Navigable Slide Index
- Introduction
- The IP3 receptor
- Types of the IP3-R throughout the evolution
- mRNA isomers through the development
- Expansion of a gene: importance of function
- IP3-R isoforms potentially exist
- The expression of the IP3-R throughtout the cell
- Different IP3-R paralogs have different distributions
- Organelles in the cell
- IP3-R identified in the ER
- The IP3-R model
- Ankrin regulates channel activity and stability
- Chromagranins (Cg): Ca binding proteins
- The physiological link between the IP3-R and Cg
- Cg has an inhibitory effect on IP3-R function
- ERP44:IP3-R interaction
- Conditions in which ERP44 regulates IP3-R
- Proteins interaction with IP3-R lumenar regions
- CAM binding peptides
- CaBPs (calbindin): neuronal EF hand
- CaBPs interact with IP3-R
- RACK1 and the heterotrimeric G protein
- IP3-R:RACK1 interaction
- Human B-cells C825T mutation for G-beta-3
- IRBIT binds IP3-R near the IP3-R binding pocket
- IRBIT is sensitive to the IP3-R binding IP3
- Proteins interact with IP3-R: myosin, IRAG, CARP
- Myosin: IP3R modulate pharyngeal pumping
- CARP: carbonic anhydrase-related protein
- CARP binding sites in the IP3-R
- IRAG: IP3-R associated cyclic GMP kinase
- CGK1-beta
- The C-terminus of IP3-R
- Ca induced apoptosis and huntigton
- PP1A regulates IP3-R phosphorylation by PKA
- Mechanism for alterations: IP3-R phosphorylation
- IP3-R as a cytoskeletal element
- The 4.1N is critical for the basal-lateral targeting
- A multitude functional proteins interact with IP3-R
- IP3R in the Golgi apparatus
- Cg, Cam and CaBPs interact with IP3-R
- Sec 6/8 are active upstream of IP3 binding site
- IP3-R and plasma membrane interaction
- TRPC channels: Homer, Bank and Junctate
- The model for IP3R-TRPC interactions
- An Inhibitory effect of TRPC on IP3-R
- Are TRPC channels coupled to the IP3-R?
- The role of IP3-R in the TRPC activation
- Junctate protein interacts with IP3-R
- Junctate stimulates Ca release
- Proteins involved in the IP3R-TRPC complex
- BANK protein activity
- Proper Ca signaling
- IP3R affects the mitochondrial Ca homeostasis
- Apoptotic and nonapoptotic proteins
- IP3R is juxtaposed to mitochondria
- Ca overload is the key to cytochrome C release
- Caspase 3 and calpein in apoptosis
- Bcl and Bcl-xl: anti-apoptotic proteins
- Proteins interact with IP3-R during apoptosis
- The nucleus
- Nuclear Ca signals are induced by hepatocytic GF
- Why is IP3R located in the nucleus?
- IP3R in calciosomes
- Calciosomes
- Why are there 23,001 isomers of IP3R?
- IP3R isomers are necessary for function specificity
- Conclusions
Topics Covered
- Activation of the IP3-receptor (IP3R), a major endoplasmic Calcium release channel in many cells, is activated by the second messenger inositol 1,4,5-trisphosphate (IP3)
- The IP3R is unique in that it can integrate signals from numerous cellular pathways via a myriad of inputs which include nucleotide binding, phosphorylation, Calcium binding and protein-protein interactions
- A diverse range of cellular functions are modulated by the IP3R including contraction/excitation, secretion, gene expression, cell cycle, apoptosis and cellular growth
- The nodal properties of the IP3R and the mechanisms by which this occurs
Talk Citation
Patterson, R. (2007, October 1). The molecular biology of the inositol trisphosphate receptor [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/DOFE8213.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Randen Patterson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.