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1. Introduction
2. Agonist-activated calcium entry
3. Store vs. non-store operated calcium channels
4. Arachidonic acid (AA) metabolism
5. Identity of AA-activated calcium channels
6. The first Arachidonic acid model
7. Angiogenesis and calcium signaling
8. Proangiogenic factor bFGF triggers calcium entry
9. Activation of tyrosine kinase receptors - effects
10. Proangiogenic calcium entry is mediated by AA
11. Different channels are involved in calcium entry
12. The Arachidonic acid model in endothelial cells
13. Nitric oxide
14. Nitric oxide's role in proangiogenic calcium entry
15. AA, NO release and calcium entry relations
16. The Arachidonic acid model is more complex
17. Biological roles of AA-activated calcium entry
18. AA- & NO-induced Ca2+ entry affects proliferation
19. CAI is an antiangiogenic compound in vivo
20. AA and tumor angiogenesis
21. ECs derived from human breast carcinoma (BTEC)
22. AA promotes BTEC tubulogenesis in vitro
23. CAI reduces AA-induced BTECs tubulogenesis
24. BTEC organization in capillary-like structures
25. Multiple roles for protein kinase A (PKA)
26. In BTECs NO is involved in calcium signaling
27. Another increase in signaling complexity
28. Differences between normal & tumor-derived ECs
29. Conclusions
30. Open questions
31. Laboratory of cellular and molecular angiogenesis

Topics Covered

• Agonist-activated calcium entry: different modes
• Synthesis and metabolism of arachidonic acid (AA)
• Properties of AA-activated calcium channels
• Other effects of AA on calcium homeostasis
• Calcium entry and cell proliferation
• AA as a critical mediator of mitogen-activated calcium entry in fibroblasts
• Role of AA-dependent calcium entry in endothelial cell proliferation and angiogenesis
• Nitric oxide, calcium entry and angiogenesis
• Regulation of proangiogenic calcium signals: a complex picture

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Munaron, L. (2011, August 16). Arachidonic acid and store-independent Ca2+ entry [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/ILEE6165.
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Publication History

• Published on October 1, 2007
• Updated on August 16, 2011

Financial Disclosures

• Dr. Luca Munaron has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.