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Printable Handouts
Navigable Slide Index
- Introduction
- Calcium signals and waves
- Signal transduction via Ca2+
- Cells utilise different sources of Ca2+ for signaling
- Ca2+ release pathways
- Ca2+ signalling via NAADP and cADPR
- Store-operated Ca2+ entry
- Calcium 'on' and 'off' mechanisms
- Ca2+ acts in different time domains
- Ca2+ signals can have different frequencies
- Ca2+ signals can have varying amplitudes
- Different spatial dimensions of Ca2+ signals
- Ca2+-induced gene transcription
- Neuronal development encoded by Ca2+ signals
- Different cells express varying 'toolkit' components
- Ca2+ signalsomes undergo self-assessment
- Cells express multiple Ca2+ release pathways
- The phosphoinositide signal transduction pathway
- Inositol 1, 4, 5-trisphosphate receptors
- InsP3 receptors are located on the ER
- Mitochondrial calcium uptake monitoring
- The mitochondrial Ca2+ uptake pathway
- Mitochondrial calcium uptake and the Krebs cycle
- Mitochondrial calcium uptake leads to apoptosis
- InsP3 receptors accelerate apoptosis
- InsP3 receptors bind multiple accessory proteins
- Bcl-2 "B cell lymphoma-2"
- Bcl-2 reduces InsP3 receptor activity
- Bcl-2 suppresses InsP3-induced Ca2+ release
- Calcium and apoptosis
- Cells express multiple Ca2+ release pathways
- Excitation-contraction coupling in cardiac muscle
- Ca2+ underlies excitation-contraction coupling (1)
- Inhomogeneous Ca2+ signals in atrial muscle (1)
- Inhomogeneous Ca2+ signals in atrial muscle (2)
- Ca2+ underlies excitation-contraction coupling (2)
- Atrial myocyte Ca2+ channel distribution
- Atrial myocyte excitation-contraction coupling (1)
- Ca2+ underlies excitation-contraction coupling (3)
- Physiological sympathetic inotropy stimulation
- Isoproterenol increases cellular contraction
- Endothelin-1 increases atrial cell contractility
- Endothelin-1 causes positive inotropy
- Positive inotropy and increased contraction in atria
- Atrial myocyte excitation-contraction coupling (2)
- Endothelin-1 causes inotropy and arrhythmias
- Endothelin-1 evokes spontaneous Ca2+ transients
- Dysrhythmias and spontaneous Ca2+ release
- Atrial myocyte at rest
- Atrial myocyte showing spontaneous Ca2+ sparks
- Spontaneous calcium signals cause depolarisation
- Further reading
Topics Covered
- Introduction to the spatial and temporal complexity of cellular calcium signals
- Calcium 'on' and 'off' mechanisms
- The calcium signaling toolkit
- Calcium sources
- Calcium waves
- Calcium oscillations
- Cell-specific calcium signaling proteomes
- Examples of calcium signaling differentially controlling cellular processes such as gene transcription and neuronal differentiation
- Inositol 1,4,5-trisphosphate receptors as an example of a calcium release system
- Mitochondrial calcium uptake
- Regulation of apoptosis by calcium
- Cardiac calcium signaling
- Atrial myocytes regulate contraction by modulating the spatial properties of their calcium signals
- Calcium-induced arrhythmias
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Talk Citation
Bootman, M. (2012, July 15). Introduction to cellular calcium signaling [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/YEBG2414.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Martin Bootman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.