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1. Introduction
2. Oxidative stress in aging: outline
3. What is aging?
4. Characteristics of aging
5. Social impact of aging studies
6. Outline: the decay of aging
7. The decay of aging
8. Decaying of physiological functions with age
9. Mitochondrial decay with aging
10. Cancer risk increases with age
11. Outline: longevity curves, life span
12. Survival curves in two populations
13. Antioxidants increase life span in Drosophila (1)
14. Outline: the theories of aging
15. Theories of aging: classification
16. Theories of aging: a review paper
17. The oxidative theories of aging
18. Outline: the free radical theory of aging
19. Free radical theory of aging: Denham Harman
20. Evidence for the oxidative damage theory (1)
21. Evidence for the oxidative damage theory (2)
22. SOD and catalase increase life span (1)
23. Females overexpress SOD and GP
24. Outline: mitochondria in age-related damage
25. Mitochondria and free radical theory of aging
26. The mitochondria
27. Mitochondrial electron transport chain
28. Mitochondrial damage
29. Peroxide production in brain mitochondria
30. Effect of age on glutathione oxidation in liver
31. Age and oxidative damage to mitochondrial DNA
32. Glutathione oxidation and damage to DNA
33. Oxidative damage to DNA correlates with MLSP
34. Mitochondria and aging: conclusion
35. Outline: markers of oxidative stress in aging
36. Oxidants as signals in cell physiology regulation
37. Outline: differential longevity between genders
38. Life expectancy over time by sex in Spain
39. Survival curve of Wistar rats
40. Effect of gender on free radical production
41. Effect of ovariectomy on free radical production
42. Estrogen replacement restores free radical level
43. Synaptic vs. non-synaptic brain mitochondria
44. Effect of gender on GSH levels in mitochondria
45. Effect of ovariectomy on GSH levels
46. Effect of estrogen replacement on GSH levels
47. Males have higher oxidative damage to mtDNA
48. Females behave as double transgenics
49. Mechanism of antioxidant regulation by estrogen
50. Estrogen at high levels acts as an antioxidant
51. Estrogens at low levels lower oxidative stress
52. Estradiol antioxidant effect is receptor-mediated
53. Estradiol activates phosphorylation of ERK
54. Estradiol activates NFkappaB
55. Up regulation of MnSOD by estrogens
56. Up regulation of GPx by estrogens
57. Mechanism of the antioxidant action of estradiol
58. Why females live longer than males?
59. Outline: interventions
60. Examples of interventions
61. Vitamin supplements: Linus Pauling
62. Evidence against vitamin supplements usage
63. Antioxidants increase life span in Drosophila (2)
64. Vitamin E increases life span in mice
65. Ability of phytoestrogens to act as antioxidants
66. Mechanism of action of genistein at cellular level
67. Prevention of peroxide production by EGb 761
68. Prevention of glutathione oxidation by EGb 761
69. Prevention of mtDNA oxidation by EGb 761
70. Regular exercise increases life span in mice
71. Caloric restriction increases life span in mice
72. SOD and catalase increase life span (2)
73. Outline: concluding remarks
74. Concluding remarks

Topics Covered

• Characteristics of aging
• The decay of aging: cellular, tissue and organism level
• The longevity curves: maximum and average life span
• The theories of aging
• The free radical theory of aging
• Mitochondrial damage
• Markers of oxidative stress in aging
• Differences in oxidative stress in aging explain the differential longevity between genders
• Interventions: antioxidant vitamins, estradiol, regular exercise, caloric restriction, antioxidant enzymes

Links

Series:

• Free Radicals and the Oxygen Paradox

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on November 1, 2007
• Archived on May 31, 2018

Financial Disclosures

• Dr. Jose Vina has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.