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Polymers as nanocarriers for controlled drug delivery

Published on November 29, 2018   47 min

A selection of talks on Methods

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0:00
Hi, my name is Marcelo Calderon. I'm Professor for Organic and Macromolecular Chemistry at the Freie Universität Berlin in Germany, and I'm an Ikerbasque Research Professor in Polymers for Biomedicine in POLYMAT, San Sebastian, Spain. Today, we'll be talking to you about polymers as nanocarriers for controlled drug delivery.
0:19
As an outline, I would like to go over the topics from today's talk. First, we will get started with the definition of polymers and their use as nanocarriers. Later, we will move to discuss the mechanisms that it could be used for drug delivery using polymers, which kind of triggers could we use for controlling the drug delivery at the site of action. Moreover, we will discuss how the different properties of the polymeric nanocarriers could influence their biological fate, and we will finalize our presentation from today by discussing some examples regarding the development of polymer-drug conjugates for anticancer therapy, the development of thermoresponsive nanogels for topical drug delivery, and moreover, the use of polymeric nanoparticles for hair follicle penetration. At the end, we will close the talk with a summary.
1:09
So the first question we have for today is what are polymers. So, polymers, as has been defined by the International Union of Pure and Applied Chemistry, are substances compose of macromolecules. They're very large, with high molecular weights ranging from few thousands to as high as millions of gram per mole. The IUPAC defined polymers as molecules of high relative molecular mass. Their structure is essentially comprised by a multiple repetition of units derived mostly by molecules from relatively low molecular mass. There are different kind of polymers. There are natural polymers and synthetic polymers. And, for sure, you know already some of natural polymers. There are proteins, starch, cellulose, and DNA. And from synthetic polymers, for sure, you know some of them that you may use when you go to supermarket. Like, for instance, nylon, polyethylene, and many others. So now, the question we have for today's discussion is how these polymers can be used for controlled drug delivery.

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