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Printable Handouts
Navigable Slide Index
- Introduction
- The world's deadliest animals
- Why are mosquito-borne diseases so deadly?
- Commonly used practices for mosquito control
- Mosquitoes as obligatory vectors
- Engineering mosquitoes to resist infection
- Engineered resistance to Zika in Aedes aegypti
- Preventing insect-borne disease
- Replacing the wild population
- The grand challenge
- Gene drive systems
- Range of gene drive systems developed
- Threshold-dependent gene drive system
- Genetic phenomenon: underdominance
- Genetic outcrossing
- Early translocation research
- Engineering translocations
- Translocation summary
- Proof of concept
- Engineered translocations spread rapidly
- Engineering translocations using CRISPR
- Inserting pathogen resistance gene
- Summary of engineered translocations
Topics Covered
- Why mosquito-borne diseases are so deadly
- Commonly used practices for mosquito control
- Engineering mosquitoes to resist infection
- Gene drive systems
- Genetic outcrossing
- Engineering translocations & use of CRISPR
- Inserting pathogen resistance genes
- Replacing the wild population
Talk Citation
Akbari, O. (2018, September 26). Engineering reciprocal chromosomal translocations to control the fate of populations [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 5, 2024, from https://doi.org/10.69645/FJHO8754.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Omar Akbari has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Engineering reciprocal chromosomal translocations to control the fate of populations
Published on September 26, 2018
28 min
Other Talks in the Series: Gene-Drives and Active Genetics
Transcript
Please wait while the transcript is being prepared...
0:00
My name is Omar Akbari,
and I'm an assistant professor at the University of California, San Diego.
Today, I'm going to talk to you about
Engineering Reciprocal Chromosomal Translocations to Control the Fate of Populations.
0:17
So, when we think about mosquitoes,
we think about disease.
In fact, when you look at the number of people killed by animals,
mosquitoes top the chart.
They are considered the world's deadliest animal and there are
roughly a million people dying every single year of a mosquito-borne vectored pathogen.
The next closest animal on the scale is humans and that has to do with wars.
0:47
So, why are mosquitoes so deadly?
Well, they transmit a number of different pathogens that affect humans including malaria.
For example, with malaria,
we see around 207 million cases per year and we do the math,
that's around a thousand people dying every single day.
Unfortunately, those are mostly children under the age of five.
Mosquitoes also transmit Dengue fever,
with dengue we have about 390 million cases per year
and that's roughly around 50,000 deaths per year.
They also transmit West Nile Virus and there's about 30,000 cases of West Nile per year.
Yellow fever, we have around 207,000 cases per year.
In total, it's estimated that 3.2 billion
people are at risk of a mosquito-borne vectored pathogen,
which is roughly half the world's population.
On the bottom here are pictures of a few of
the very deadly mosquito species, including Aedes aegypti,
an Aedes albopictus which are the top Dengue vectors,
and in the middle there is Anopheles Gambiae which is the main malaria vector in Africa.
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