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Printable Handouts
Navigable Slide Index
- Introduction
- Spread of a gene drive
- Gene drive
- Gene drive types
- Applications (1)
- Applications (2)
- Homing drive
- Resistance
- Haplolethal homing drive
- Haplolethal homing mechanism
- Suppression experiment
- Driving Y/X-shredder
- Genetic load “suppressive power”
- More powerful suppression
- Complex environments
- Population suppression
- Complex environments
- Drive comparison
- Toxin-antidote dominant sperm (TADS) drive
- Confined drives
- Levels of confinement
- Spatial confinement
- Toxin-antidote recessive embryo (TARE) drive
- TARE drive
- 2-drive TARE systems
- Two deme confinement
- Tethered drive
- TADE suppression drive
- Spatial TADE suppression
- CRISPR TA drive thresholds
- Wolbachia CifAB drive
- Further reading
- Acknowledgements
Topics Covered
- Gene drive types
- Applications of gene drives
- CRISPR/Cas9
- Haplolethal homing drive
- Suppression experiment
- TADS drive
- Levels of confinement
- TARE drive
- 2-drive TARE systems
- Wolbachia CifAB drive
Links
Series:
Categories:
Talk Citation
Champer, J. (2024, May 30). Different types of gene drives [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/JSHG4701.Export Citation (RIS)
Publication History
Financial Disclosures
- There are no commercial/financial matters to disclose.
Other Talks in the Series: Gene-Drives and Active Genetics
Transcript
Please wait while the transcript is being prepared...
0:00
Hello. I'm Jackson Champer,
a scientist at Peking University
and I'd like to tell you
a little bit about the
many different types
of gene drives available.
My hope is that even
though we won't cover
every single possible
type of gene drive
in this talk that
after listening,
you'll get a better idea of
many different possibilities
for gene drive
and what some of the
unique advantages
of the different types
of gene drives are.
0:29
First of all, what
is a gene drive?
A gene drive is
an engineered genetic
construct that can be
placed into an individual
making it a transgenic
gene drive individual.
We can then take some of
these individuals with
gene drive and release it
into a wild-type population.
Over time, the gene
drive is then able
to bias its inheritance
and increase in
frequency in the
population until
eventually potentially
all the individuals
in that population will
have the gene drive.
This makes it a potentially very
powerful tool for manipulating
wild populations with
only a very small effort
needed, just the release
of a few individuals.
1:15
Here's an example showing
normal Mendelian inheritance.
Here your orange allele
is a heterozygote.
That means this individual has
one special allele and one
normal wild-type allele.
Half of the offspring then
will receive this
normal allele in
each generation and that
means if there's
no fitness costs,
this normal allele is
expected to stay at
the same frequency
in the population.
This gene drive
example shows what
might happen if you have
a powerful gene drive.
This red allele here even
though it's a heterozygote,
this red allele actually
is passed on to all of
the offspring and because
that happens in
every generation,
your gene drive is able to very
rapidly increase in frequency.