• General Virology
• 46 min
  1. Principles of virology

  • Prof. Vincent Racaniello
• 36 min
  2. Antiviral drugs (non-HIV)

  • Prof. Megan Shaw
• 36 min
  3. The type I interferon system and viruses

  • Dr. Adolfo Garcia-Sastre
• 45 min
  4. Immune responses to viruses

  • Prof. Paul Klenerman
• Emerging Pathogens
• 29 min
  5. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide

  • Dr. Marietjie Venter
  • Mrs. Orienka Hellferscee
• 37 min
  6. Emerging respiratory viruses - discoveries between 2001 and 2005

  • Prof. Ron Fouchier
• 28 min
  7. Usage of vaccines and therapeutics in public health emergencies 1

  • Prof. Gary Kobinger
• 39 min
  8. Usage of vaccines and therapeutics in public health emergencies 2

  • Prof. Gary Kobinger
• 50 min
  9. Influenza virus pandemics: past and future

  • Prof. Peter Palese
• 63 min
  10. SARS-CoV and other emerging coronaviruses

  • Prof. Ralph Baric
• 36 min
  11. Dengue, Zika and Chickungunya viruses

  • Prof. Ana Fernandez-Sesma
• 41 min
  12. Biodefense challenges

  • Dr. David Franz
• Important Pathogens and their Diseases
• 38 min
  13. Natural history and pathogenesis of herpes virus infections

  • Prof. Richard Whitley
• 40 min
  14. Cytomegalovirus biology

  • Prof. Domenico Tortorella
• 46 min
  15. Hepatitis C virus: discovery, cure and protection

  • Dr. Matthew Evans
• 32 min
  16. Fundamentals of HIV biology

  • Prof. Viviana Simon
• 44 min
  17. Measles

  • Prof. Diane E. Griffin
• New Frontiers
• 45 min
  18. HPV vaccines to prevent cervical cancer and other HPV-associated diseases

  • Dr. John Schiller
• 55 min
  19. Prevention of Varicella and Zoster by vaccination: Now you see it, now you don't

  • Prof. Anne Gershon
• 30 min
  20. Viruses as anticancer weapons

  • Prof. Roberto Cattaneo
• 48 min
  21. Novel approaches to diagnosis of viral infections

  • Prof. W. Ian Lipkin
• Archived Lectures *These may not cover the latest advances in the field
• 43 min
  22. Principles of virology I

  • Prof. Richard Condit
• 43 min
  23. Principles of virology II

  • Prof. Richard Condit
• 36 min
  24. Complex DNA viruses: herpes virus

  • Dr. John Blaho
• 38 min
  25. Adeno-associated viruses (AAV)

  • Prof. Kenneth Berns
• 60 min
  26. Poxviruses: smallpox (variola), vaccinia and monkeypox

  • Prof. Paula Traktman
• 26 min
  27. Can HPV testing be the sole primary cervical screening modality?

  • Prof. Jack Cuzick
• 29 min
  28. From viruses to oncolytics

  • Prof. Roberto Cattaneo
• 38 min
  29. Non HIV antivirals

  • Prof. Mary Klotman
• 42 min
  30. Gastroenteritis viruses

  • Prof. Mary Estes
• 46 min
  31. Biodefense challenges

  • Dr. Connie Schmaljohn
• 32 min
  32. Papillomaviruses and HPV vaccination to prevent cervical cancer and other HPV-associated diseases

  • Dr. Douglas Lowy
• 49 min
  33. The past, present and future of vaccination

  • Prof. Stanley Plotkin
• 41 min
  34. Filoviruses

  • Dr. Christopher Basler
• 41 min
  35. Bunyaviruses

  • Prof. Richard Elliott
• 41 min
  36. The immunobiology of HIV

  • Prof. Norman Letvin
• 59 min
  37. Hepatitis C and HCV

  • Prof. Stanley Lemon

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The spectrum of hepatitis viruses
3. Pathologic events in chronic hepatitis C
4. Global distribution of HCV infection
5. Emergence of HCV-related liver cancer
6. Liver cancer rates in the U.S. by race and sex
7. Hepatitis C pathogenesis: cellular level
8. Hepatitis C pathogenesis: system level
9. Hepatitis C pathogenesis: host consequences
10. HCV model systems
11. Hepatitis C virus
12. Cis-acting RNA elements of HCV
13. HCV 5' RNA structure
14. Translation of HCV genome vs. cellular mRNA
15. HCV IRES - 40S subunit binding affinity
16. IRES binding alters 40S conformation
17. Role of 3' terminal stem-loops of HCV RNA
18. HCV proteins hypothetical membrane topology
19. Hepatitis C virus structural proteins
20. Core protein
21. "F" protein
22. HCV envelope proteins
23. p7 protein: a target for drug discovery?
24. NS2 protein
25. NS2/3 proteinase
26. NS3 protein
27. NS3/4A proteinase
28. NS3/4A processing of nonstructural proteins
29. NS3 helicase/NTPase
30. Bifunctional NS3/4A proteinase/helicase
31. NS4A protein
32. NS4B protein
33. NS5A protein
34. NS5B RNA-dependent RNA polymerase
35. Hepatitis C virus life cycle
36. Polyprotein functions in the viral lifecycle
37. Subgenomic HCV replicon polyprotein
38. Dicistronic subgenomic HCV replicons
39. Subgenomic HCV replicon life cycle
40. HCV-infected Huh-7.5 hepatoma cells
41. Host factors - pathogenesis and viral replication
42. Cytoplasmic colocalization of Rb and NS5A
43. Viral persistence - central issue in hepatitis C
44. Possible mechanisms of HCV persistence
45. Virus-activated pathways lead to IFN synthesis
46. Suppression of HCV viremia with BILN 2061
47. Summary and conclusions

Topics Covered

• The spectrum of hepatitis viruses
• Global distribution of HCV infection
• Associated diseases
• Hepatitis C pathogenesis
• HCV model systems
• Replication of HCV RNA
• Hypothetical membrane topology of HCV proteins
• HCV structural proteins
• p7 protein
• Hepatitis C virus life cycle
• Polyprotein functions in the viral life cycle
• Subgenomic HCV replicon life cycle
• The central issue in hepatitis C is viral persistence
• Possible mechanisms of HCV persistence

Links

Series:

• Viruses and Viral Diseases

Categories:

• Clinical Practice
• Microbiology

Therapeutic Areas:

• Gastroenterology & Nephrology
• Infectious Diseases

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on August 31, 2020

Financial Disclosures

• Prof. Stanley Lemon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.