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Printable Handouts
Navigable Slide Index
- Introduction
- The spectrum of hepatitis viruses
- Pathologic events in chronic hepatitis C
- Global distribution of HCV infection
- Emergence of HCV-related liver cancer
- Liver cancer rates in the U.S. by race and sex
- Hepatitis C pathogenesis: cellular level
- Hepatitis C pathogenesis: system level
- Hepatitis C pathogenesis: host consequences
- HCV model systems
- Hepatitis C virus
- Cis-acting RNA elements of HCV
- HCV 5' RNA structure
- Translation of HCV genome vs. cellular mRNA
- HCV IRES - 40S subunit binding affinity
- IRES binding alters 40S conformation
- Role of 3' terminal stem-loops of HCV RNA
- HCV proteins hypothetical membrane topology
- Hepatitis C virus structural proteins
- Core protein
- "F" protein
- HCV envelope proteins
- p7 protein: a target for drug discovery?
- NS2 protein
- NS2/3 proteinase
- NS3 protein
- NS3/4A proteinase
- NS3/4A processing of nonstructural proteins
- NS3 helicase/NTPase
- Bifunctional NS3/4A proteinase/helicase
- NS4A protein
- NS4B protein
- NS5A protein
- NS5B RNA-dependent RNA polymerase
- Hepatitis C virus life cycle
- Polyprotein functions in the viral lifecycle
- Subgenomic HCV replicon polyprotein
- Dicistronic subgenomic HCV replicons
- Subgenomic HCV replicon life cycle
- HCV-infected Huh-7.5 hepatoma cells
- Host factors - pathogenesis and viral replication
- Cytoplasmic colocalization of Rb and NS5A
- Viral persistence - central issue in hepatitis C
- Possible mechanisms of HCV persistence
- Virus-activated pathways lead to IFN synthesis
- Suppression of HCV viremia with BILN 2061
- Summary and conclusions
Topics Covered
- The spectrum of hepatitis viruses
- Global distribution of HCV infection
- Associated diseases
- Hepatitis C pathogenesis
- HCV model systems
- Replication of HCV RNA
- Hypothetical membrane topology of HCV proteins
- HCV structural proteins
- p7 protein
- Hepatitis C virus life cycle
- Polyprotein functions in the viral life cycle
- Subgenomic HCV replicon life cycle
- The central issue in hepatitis C is viral persistence
- Possible mechanisms of HCV persistence
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Talk Citation
Lemon, S. (2007, October 1). Hepatitis C and HCV [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 13, 2024, from https://doi.org/10.69645/THZC5637.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Stanley Lemon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.