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- General Virology
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46 min
1. Principles of virology- Prof. Vincent Racaniello
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36 min
2. The type I interferon system and viruses- Dr. Adolfo Garcia-Sastre
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45 min
3. Immune responses to viruses- Prof. Paul Klenerman
- Emerging Pathogens
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29 min
4. Emerging or newly discovered viral causes of acute lower respiratory tract infections worldwide- Dr. Marietjie Venter
- Mrs. Orienka Hellferscee
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37 min
5. Emerging respiratory viruses - discoveries between 2001 and 2005- Prof. Ron Fouchier
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28 min
6. Usage of vaccines and therapeutics in public health emergencies 1- Prof. Gary Kobinger
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39 min
7. Usage of vaccines and therapeutics in public health emergencies 2- Prof. Gary Kobinger
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50 min
8. Influenza virus pandemics: past and future- Prof. Peter Palese
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63 min
9. SARS-CoV and other emerging coronaviruses- Prof. Ralph Baric
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36 min
10. Dengue, Zika and Chickungunya viruses- Prof. Ana Fernandez-Sesma
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43 min
11. Paramyxoviruses: biology & pathogenesis- Prof. Benhur Lee
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36 min
12. Antiviral drugs (non-HIV)- Prof. Megan Shaw
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41 min
13. Biodefense challenges- Dr. David Franz
- Important Pathogens and their Diseases
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38 min
14. Natural history and pathogenesis of herpes virus infections- Prof. Richard Whitley
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40 min
15. Cytomegalovirus biology- Prof. Domenico Tortorella
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46 min
16. Hepatitis C virus: discovery, cure and protection- Dr. Matthew Evans
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32 min
17. Fundamentals of HIV biology- Prof. Viviana Simon
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44 min
18. Measles- Prof. Diane E. Griffin
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42 min
19. Monkeypox virus, vaccines, and therapeutics- Prof. Rachel Roper
- New Frontiers
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45 min
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55 min
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30 min
22. Viruses as anticancer weapons- Prof. Roberto Cattaneo
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48 min
23. Novel approaches to diagnosis of viral infections- Prof. W. Ian Lipkin
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36 min
24. The Global Virus Network: collaboration to address pandemic and regional threats- Prof. Sten H. Vermund
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31 min
25. Elite controllers of HIV: from discovery to future therapies- Prof. Bruce Walker
- Archived Lectures *These may not cover the latest advances in the field
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43 min
26. Principles of virology I- Prof. Richard Condit
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43 min
27. Principles of virology II- Prof. Richard Condit
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36 min
28. Complex DNA viruses: herpes virus- Dr. John Blaho
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38 min
29. Adeno-associated viruses (AAV)- Prof. Kenneth Berns
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60 min
30. Poxviruses: smallpox (variola), vaccinia and monkeypox- Prof. Paula Traktman
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26 min
31. Can HPV testing be the sole primary cervical screening modality?- Prof. Jack Cuzick
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29 min
32. From viruses to oncolytics- Prof. Roberto Cattaneo
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38 min
33. Non HIV antivirals- Prof. Mary Klotman
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42 min
34. Gastroenteritis viruses- Prof. Mary Estes
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46 min
35. Biodefense challenges- Dr. Connie Schmaljohn
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32 min
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49 min
37. The past, present and future of vaccination- Prof. Stanley Plotkin
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41 min
38. Filoviruses- Dr. Christopher Basler
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41 min
39. Bunyaviruses- Prof. Richard Elliott
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41 min
40. The immunobiology of HIV- Prof. Norman Letvin
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59 min
41. Hepatitis C and HCV- Prof. Stanley Lemon
Printable Handouts
Navigable Slide Index
- Introduction
- Topics to be covered
- Rationales for the study of Poxviruses
- Poxvirus taxonomy
- Poxvirus life cycle
- Chromosome organization
- The terminal region of the chromosome
- Virion structure
- Virus entry
- Viral proteins needed for entry
- Mechanism of EV entry
- Gene expression
- Temporal profile of gene expression
- Early gene transcription
- Intermediate and late gene transcription
- Working model of DNA replication
- The Poxvirus replication apparatus
- Schematic of the core replication apparatus
- Intracellular localization of genome replication
- Schematic of Poxvirus morphogenesis
- EM image of Poxvirus morphogenesis
- Key features of early morphogenesis
- Visualization of the D13 lattice
- Key features of the IV to MV transition
- Poxvirus-mediated disulfide bond formation
- Formation of extracellular virions
- Vaccinia virus egress
- Mechanism of EV release and spread
- Cytopathic effects of Orthopoxvirus infection
- Repertoire of Poxvirus immunomodulators
- Immunomodulators and disease
- Animal models of Poxvirus infection
- Smallpox - epidemiology
- Smallpox disease
- Vaccinia vs. Variola
- Poxvirus vaccination
- WHO smallpox recognition card
- Declaration of smallpox eradication
- Monkeypoxvirus
- Antipoxvirus therapy
- Rationale for the experimental study of Poxviruses
- Figure citations
Topics Covered
- Poxvirus life cycle: chromosome structure, virion structure and virion entry
- Viral proteins needed for entry and mechanism of entry of EV (enveloped virion)
- Gene expression of EV: early transcription, intermediate and late transcription
- Working model of Poxvirus genome replication
- Morphogenesis of EV
- Key features of the IV to MV (mature virions) transition
- Poxviruses encode a three-protein complex that generates disulfide bonds in the cytoplasm
- Formation of EEV (extracellular enveloped virions) and EV mediators of cell-to-cell and distal spread
- Poxviruses encode a large array of immunomodulators
- Models for the study of Poxvirus pathogenesis
- Smallpox (Variola virus) and smallpox disease
- Pathogenicity of Variola virus vs. Vaccinia virus
- Official declaration of the eradication of smallpox
- Monkeypox virus
- Antiviral therapy and new vaccines for Poxviruses
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Traktman, P. (2007, October 1). Poxviruses: smallpox (variola), vaccinia and monkeypox [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/TUGX7084.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Paula Traktman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
