Coagulation in sepsis

Published on October 31, 2016   39 min

Other Talks in the Series: Topical Talks

Good day, this is Marcel Levi, from the Academic Medical Center of the University of Amsterdam in the Netherlands. And I'm going to present a talk on the coagulopathy associated with sepsis.
In systemic inflammatory states, as may be the case in patients with severe infection or even sepsis, there is always some degree of coagulation activation. This can be detected when you use sensitive assays for molecular markers of activated coagulation factors or pathways. But if it's sufficiently severe, you're also going to see laboratory abnormalities in routine coagulation tests like the platelet count or prolongation of the global clotting tests, APTT and PT, and in its most extreme form, disseminated intravascular coagulation may occur.
Actually what we see in the laboratory, especially in the routine laboratory, is probably the tip of the iceberg. Under the surface, there is a lot of coagulation activation that may be clinically relevant, present in patients with severe infection and sepsis and the associated systemic inflammatory states.