Transport mechanism of urate in humans

Published on May 31, 2016   52 min

Other Talks in the Category: Clinical Medicine

Hello, my name is Hiroyuki Saturai, professor of pharacology, Kyorin University School of Medicine, Tokyo, Japan. Today, I'd like to discuss urate transport in our body. I will try hard to explain physiological principles of urate transport so that my talk is applicable not only to urate, but also to many negatively charged xenobiotics or endogenous substrate.
So this is the agenda for this talk. I will briefly discuss about what urate is doing in our body. Then we move to the physiology of trans-epithelial movement of the solute. Then I will come back to urate handling and especially in the two key organs in urate metabolism, kidney and the intestine. Then I will finish with drugs that affect urate transport, either a treatment or a side effect.