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The blood-retinal barrier
Published on April 27, 2016 18 min
Other Talks in the Series: Biology of the Eye
Lens development and disorders - molecular biology and genetics
- Dr. Rachel Gillespie
- University of Manchester, UK
On this series of lectures on biology of the eye, I will review the blood-retinal barrier, which will go along with this structure, function, and also its relevance to retinal diseases.
Eye disclosures are next.
And then, after, we will go on to the initial experiment that has been done with trypan blue in the brain. And this was repeated by us later on in the retina and choroid. And you can see that trypan blue penetrates in to the lungs and colors the lungs and other tissues of the body like the heart, but does not stain the brain or stains with the retina that you can see on the fourth, down in the picture.
The next slide shows you that the relationship between what I will describe afterwards, as the inner blood-retinal barrier and outer blood-retinal barrier join the endothelial, the relationship between retina and the blood capillary in the capillaries of the retinal vessel and the retinal vessels and in the relationship with retinal pigment epithelium. And you will see that it communicates between these layers and this extracellular fluid within the retina.
We, at that time in initial studies, in first studies were done in '66, '67, we showed there was an efflux outflow of, by active transport from organic anions like fluorescein, out of the vitreous in to the retina, involving the retinal pigment epithelial and the retinal vessels.