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- Epidemiology
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2. Epidemiology of obesity
- Prof. Jacob Seidell
- Etiology and Causes
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3. Metabolic, adipose tissue and muscle predictors of obesity
- Prof. Ian Macdonald
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4. Neural control of food intake and energy balance
- Prof. Hans-Rudolf Berthoud
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6. Dietary determinants of obesity
- Prof. Arne Astrup
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7. Physical inactivity as a determinant of obesity
- Prof. Wim Saris
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8. Environmental causes of obesity: sociocultural, built environment and economic factors
- Prof. Shiriki Kumanyika
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9. The developmental origins of obesity
- Prof. David Barker
- Consequences of Obesity
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10. Obesity, dyslipoproteinemia and inflammation
- Prof. Robert Eckel
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11. Pathophysiology and management of obesity related hypertension
- Prof. Arya Sharma
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12. Disorders of overeating
- Prof. Albert Stunkard
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13. Obesity, weight loss and health-related quality of life
- Prof. Aila Rissanen
- Dr. Jarmo Kaukua
- Treatment Options
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14. Lifestyle modification for weight control
- Prof. Thomas Wadden
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15. Bariatric / obesity surgery
- Prof. Henry Buchwald
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16. Can obesity be prevented in the current obesogenic environment?
- Prof. Boyd Swinburn
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17. Pharmacotherapy for obesity: why it is needed
- Prof. Joe Proietto
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18. Pharmacotherapy for obesity: hunger suppressors
- Prof. Joe Proietto
- Latest Developments in the Field
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19. Body composition
- Dr. Steven Heymsfield
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20. Adipose tissue metabolism and obesity
- Dr. Max Lafontan
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21. Obesity, present and future therapies
- Prof. Sir Stephen Bloom
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22. Energy expenditure in the lean and obese
- Prof. Dale Schoeller
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23. Obesity and adiponectin
- Prof. Philipp Scherer
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24. Ectopic fat: causes, consequences and treatment
- Prof. Steven Smith
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25. Adipose-immune interactions in obesity
- Dr. Vishwa Dixit
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26. Health benefits of intentional weight loss
- Prof. Xavier Pi-Sunyer
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27. Childhood obesity: implications for current and future health
- Prof. Peter T. Katzmarzyk
- Archived Lectures - These lectures may not cover the latest advances in the field
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29. Gastrointestinal peptides and food intake regulation
- Prof. Sir Stephen Bloom
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30. Obesity and mortality: questions and controversy
- Prof. David Allison
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31. Obesity, diabetes and the cluster of the metabolic syndrome
- Prof. Peter Wilson
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33. Health economics of obesity: new insights
- Dr. Anne Wolf
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34. Bariatric surgery: techniques and mechanisms of action
- Prof. Walter Pories
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35. Childhood obesity: implications for future health
- Prof. Peter T. Katzmarzyk
Printable Handouts
Navigable Slide Index
- Introduction
- Why do we over eat?
- Over eating in the media
- Over eating in children
- Epidemic sweeping the world
- 3 billion obese people
- USA obesity rates
- Global prevalence of obesity - adult males
- Why is obesity bad?
- Prevalence of obesity and diabetes - U.S. adults
- Change in county life expectancy (women)
- Advice to the obese
- Past obesity drugs
- Present obesity drugs in EU
- Marketed GLP1 mimetics
- Drugs approved for obesity in USA: 09/2014
- Qsymia
- Medical failure
- What does “cure” obesity?
- List of bariatric surgeries
- Bariatric bypass surgery: only successful therapy
- Bariatric bypass surgery - disadvantages
- Future obesity drugs
- The gut hormones
- fMRI of brain regions after satiety hormone infusion
- “Curing” diabetes
- Summary: contrlling human motivation
Topics Covered
- Gut hormones regulate appetite as well as gut function
- Satiety, appetite control
- New therapeutic opportunities via gut hormones
- Bariatric surgery
- Mechanism of action, obesity increasing and threatens health
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bloom, S. (2015, November 30). Obesity, present and future therapies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 20, 2025, from https://doi.org/10.69645/SECJ7415.Export Citation (RIS)
Publication History
- Published on November 30, 2015
Financial Disclosures
- Prof. Sir Stephen Bloom, Grant/Research Support (Principal Investigator): Medical Research Council
A selection of talks on Clinical Practice
Transcript
Please wait while the transcript is being prepared...
0:00
"Obesity,
Present and Future Therapies."
I'm Steve Bloom
and I'm a physician
who looks after patients
with diabetes
at Hammersmith Hospital
in North London,
but I'm also an academic
and my research area
in Imperial College, London,
is the mechanisms
by which we control our appetite
with a view
to trying to cure obesity.
0:29
So one of the first questions
to ask is why do we over eat?
Well, in a nutshell,
it's summer all the time.
So mankind tends to have
more children than the parents,
so an average set of parents
will have six, seven,
eight, nine children.
During evolution,
there wasn't of course
a constant increase of food
and so these children
had to fight
for the food source.
In a good year,
they would all survive,
but when the rains
failed for a few years,
they were subject
to chronic starvation.
And only those
who conserved energy
and grabbed all the food
they could, survived
and passed on their genes
to the current
Homo sapiens populations,
so we are the inheritors of,
shall we say, sloth and greed,
but this is
a natural circumstance
to make the energy go further.
We've now changed
the environment.
There's delicious,
high calorie food available
24 hours a day
and absolutely
no need for exercise.
You go up in the elevator,
et cetera.
So the consequences are
that we're all becoming obese.
We haven't evolved to be obese.
We evolved
to be fighting for food
and everybody very thin.
Unfortunately, our metabolism
is suited for this thin habitus.
And we now, therefore,
have a metabolic disequilibrium
which causes early death
due to obesity.