0:00
Hi, this is Lei Yang.
I'm currently a professor
at the Orthopedic Institute
and Department of Orthopedics,
the First Affiliated Hospital,
Soochow University in China.
And the title of my talk
today is New Nano Biomaterials
Inspired by Biomechanics.
0:20
This is the outline
for today's talk.
I'm going to cover several
parts on this topic.
First I will begin with
a brief introduction
to some basic concepts
of biomechanics.
Secondly, I would like
to introduce two examples
of new nano biomaterials
that have been
developed inspired by biomechanics.
In the first example
I'm going to talk
about design of nanomaterial
topographic guidance
to regulate cell functions.
And the second one where we give
an example of thermodynamically
inspired nanocrystalline diamond
for controlling cell migration.
And last, I will give you a
brief summary on this topic.
1:04
Please allow me to introduce
you to some basic concepts
and why we want to use biomechanics
to design the new biomaterials.
1:16
The role of the mechanics
in biology is very obvious.
And many people has realized
that mechanics actually
play an important role in
a variety of biological
and physiological processes.
For example, in any
physical injuries,
they're probably
involved in mechanics.
When we are talking about a bone
fracture, the torn cartilage
or ligaments, there
is always high energy
impacts, or high stress or strain
involved in those injuries.
When we're talking about a
cardiovascular disease, which
is just showing in
the picture, there is
fluid mechanics involved in this.
When people are designing
the cardiovascular stents,
you always have to consider how
the blood flow as it goes through
and it goes around those
man-made materials.
And surprisingly, in cancer
development mechanics
actually play a role in it too.
Scientists has recently discovered
that the cancer cells have
completely different
mechanical properties compared
to other types of normal cells.
So looking at mechanics actually
can give us a lot of insights to how
the cancer has been developed, and
finding out the way to fighting it.
In the last example, which is
showing in the lower right image
here the head trauma and
brain damage, obviously
you understand when
the trauma happens,
when your head hit on a
wall, there is a coup
injury at the front of your head.
However, not many
people have realized
that because of the viscoelastic
property of your brain,
your brain actually
will bounce back and hit
the rear parts of your skull.
And this will introduce a
counter coup injury.
So all these examples tell you the
mechanics plays a very important
role in the tissue or organ level,
and sometimes in your whole body
biological processes.
So how about the mechanics
at a smaller level?
