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0:00
Hello, my name is
Axel Kornerup Hansen.
I'm a professor and the
board chairman of science
at the University of Copenhagen.
In this lecture, I will
introduce you to the impact
that the microbiome
has on animal models,
and how we can improve
your work with these models
by considering these aspects.
In principle, this could be
about models in various species.
But I will focus on rodents, because
they outnumber other model species,
because there are
those who are primarily
used for their low variation, and
high potential for standardisation,
and also because this is
what I'm actually working
with in my own research group.
0:36
In this lecture, I will
start out by talking
about how bacteriological monitoring
is done in laboratory rodents
today.
And after that, I will introduce
to the fascinating world
of the gut microbiota.
I will talk about the impact
that this microbiota has
in rodent models, and give
a short and very incomplete
impression on how this interaction
between the host and the microbiota
may take place.
And introduce you to how
much variation actually
causes in your rodent models,
and I will end up presenting
some plausible ways
to deal with this impact.
1:13
Bacteria are a source of variation
in laboratory animal work.
This is not a new issue,
and the systematic handling
of the variation caused
by bacteria has developed
from the beginning of the 20th
century, through the millennium,
and up till today.
However, there's still
much which can be done.
So let me start out by shedding
a critical light on the states
at which we are today in
laboratory animal breeders,
be it facilities,
or be it scientists.
