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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Outline of talk
- Caspase pathways: intervention points
- Overview of caspase family members
- Caspase pathways: apoptotic and inflammation
- Optimal substrate sequence specificity
- Peptide based inhibitors: reversible
- Peptide based inhibitors: irreversible
- Indications in which caspases have been implicated
- Which indications are likely?
- What is myocardial infarction?
- Caspase inhibition: therapeutic intervention in MI
- What is a stroke/ischemia?
- Use of animal models for stroke/ischemia
- Caspase inhibition: therapeutic intervention-stroke
- Liver disease
- Sepsis
- What is rheumatoid arthritis?
- Caspase' role in rheumatoid arthritis
- Psoriasis
- Structure of generic small molecule inhibitors
- Generic inhibitors: warhead and aspartic acid (1)
- Reversible/irreversible warheads
- Generic inhibitors: warhead and aspartic acid (2)
- Compounds lacking a P1 aspartic acid (1)
- Compounds lacking a P1 aspartic acid (2)
- Noncompetitive binding inhibitors
- Overview of small molecule efforts: Pfizer
- Pfizer compounds (1)
- Pfizer compounds (2)
- Overview of small molecule efforts: Merck
- Merck compounds (1)
- Merck compounds (2)
- Overview of small molecule efforts: Sunesis
- Sunesis compounds
- Sunesis: advancement of molecules
- Sunesis: caspase-1 inhibitors
- Overview of small molecule efforts: Idun
- Idun compounds (1)
- Idun compounds (2)
- IDN-6556
- IDN-6556: clinical progress
- Overview of small molecule efforts: Vertex
- Vertex compounds: VX-740
- VX-740: in-vivo data
- VX-740: clinical progress
- Vertex compounds: VX-765
- Key issues
- Going forward
Topics Covered
- Apoptotic caspases
- Inflammatory caspases
- Validation of caspase involvement in disease
- Animal models
- Rheumatoid arthritis
- Liver degeneration
- Small molecule drug discovery
- Inhibitor specificity
- Reversible and irreversible binding inhibitors
- Clinical trial data
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
O'Brien, T. (2007, October 1). Caspase inhibitors in drug discovery [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2024, from https://hstalks.com/bs/297/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Tom O'Brien has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.