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Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Three types of bone cells
- Defining the three types of bone cells
- Osteocyte ontogeny
- Osteocytes
- Canalicular network
- Osteocyte lacuno-canalicular, vascular systems
- The perilacunar matrix
- Osteocyte pioneers in history
- First proposed function - osteocytic osteolysis
- Study of osteocytes between 1970s to 2000s
- Technology today
- Technology used for studying osteocytes
- Osteocytes remove & replace perilacunar matrix
- Osteocytes express genes used for resorption
- Changes in the osteocyte microenvironment
- The osteocyte network
- Osteocytes as mechanosensory cells
- Bone adapts to strain
- Medical problem: osteoporosis
- Mechanical load & changes in bone mass
- Theory of mechanical load & bone mass changes
- Osteocyte lacuno-canalicular network
- What form of strain occurs in bone?
- Fluid flow shear stress
- What Wnt/b-catenin pathway is important for
- Wnt/b-catenin pathway & mechanical load
- Sost/sclerostin: highly expressed in osteocytes
- Mutation/deletion of Sost: increased bone mass
- Neutralizing antibody to Sclerostin
- RANK & RANKL
- RANKL is critical for osteoclast formation
- MLO-Y4 osteocyte-like cells
- RANKL is expressed on MLO-Y4 cells
- Regulation of bone homeostasis through RANKL
- Osteocytes as endocrine cells
- Osteoblast to osteocyte differentiation
- Early embedding cells express PHEX and DMP1
- PHEX & DMP1
- FGF23 elevated in osteocytes and systemically
- DMP1 and PHEX regulate circulating FGF23
- The PHEX-DMP1-FGF23 axis
- Pathological roles of FGF23
- Role FGF23 in chronic kidney disease
- Pathological roles of FGF23 - summary
- Osteocytes are endocrine cells & target muscle
- Myoblasts differentiation into myotubes
- Isolated primary muscle: EDL and SOL
- Bone to muscle cross talk
- Osteocytes as endocrine cells - summary
- Osteocytes are multifunctional
- More recent publications
- Acknowledgements
- Funding sources
Topics Covered
- Osteocyte description & research history
- Technology used for studying osteocytes
- Osteocytic osteolysis
- Osteocytes as mechanosensory cells
- Osteocytes as secretory cells regulating skeletal remodeling
- Osteocytes as endocrine cells that target kidney and muscle
Talk Citation
Bonewald, L.F. (2015, January 19). The osteocyte [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 7, 2024, from https://doi.org/10.69645/GNKF3830.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Lynda F. Bonewald has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Other Talks in the Series: Bone in Health and Disease
Transcript
Please wait while the transcript is being prepared...
0:00
Hello,
my name is Lynda Bonewald.
And I'm from the University
of Missouri at Kansas City.
And the title of my
talk is The Osteocyte.
0:12
First, I would like to give you
an outline of the presentation.
I'll talk about
osteocytes in history,
their first proposed function,
that of osteocytic osteolysis,
their second proposed function,
that of mechanosensation,
then about how osteocytes can
serve as secretory cells regulating
skeletal remodeling
through molecules,
such as sclerostin and RANKL, fifth,
how osteocytes are endocrine cells
that can target kidney and muscle.
And finally, I will summarize
the functions of osteocytes.
0:50
Now, there are three
types of bone cells.
There are the osteoclasts
that resorb bone
and the osteoblasts that make bone.
And then there is the third the
cell type called the osteocyte.
1:05
Osteoclasts and osteoblasts
are defined by their function.
Osteoclasts resorb bone
and osteoblasts make bound.
However, osteocytes are
defined by their location.
So this implies a lack of
knowledge regarding their function.
1:23
This slide shows osteocyte ontogeny.
The osteocyte is descended
from the pre-osteoblast, which
differentiates into the
matrix-producing osteoblast.
And by some unknown mechanism, some
of these cells become osteocytes.
And then once they're surrounded by
osteoid, they begin to mineralize.
And once surrounded by mineral,
they are called mature osteocytes.