The osteocyte

Published on January 19, 2015   34 min

Other Talks in the Series: Bone in Health and Disease

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Hello, my name is Lynda Bonewald. And I'm from the University of Missouri at Kansas City. And the title of my talk is The Osteocyte.
First, I would like to give you an outline of the presentation. I'll talk about osteocytes in history, their first proposed function, that of osteocytic osteolysis, their second proposed function, that of mechanosensation, then about how osteocytes can serve as secretory cells regulating skeletal remodeling through molecules, such as sclerostin and RANKL, fifth, how osteocytes are endocrine cells that can target kidney and muscle. And finally, I will summarize the functions of osteocytes.
Now, there are three types of bone cells. There are the osteoclasts that resorb bone and the osteoblasts that make bone. And then there is the third the cell type called the osteocyte.
Osteoclasts and osteoblasts are defined by their function. Osteoclasts resorb bone and osteoblasts make bound. However, osteocytes are defined by their location. So this implies a lack of knowledge regarding their function.
This slide shows osteocyte ontogeny. The osteocyte is descended from the pre-osteoblast, which differentiates into the matrix-producing osteoblast. And by some unknown mechanism, some of these cells become osteocytes. And then once they're surrounded by osteoid, they begin to mineralize. And once surrounded by mineral, they are called mature osteocytes.