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This presentation deals
with pharmacometrics in psychiatry.
My name is Lesbeth de Lange, and I
work at the Leiden Academic Center
of Drug Research at the
Systems Pharmacology Cluster
the Division of Pharmacology
at Leiden University.
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The outline of this
presentation is as follows.
First I will talk about psychiatric
disorders, a little about genetics,
then psychoactive drugs,
diagnosis and treatment,
pharmacometric approaches,
and then some discussion,
and then some recommendations
to a better treatment.
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The term "psychiatric disease"
is used when mental illness
significantly interferes with
the performance of major life
activities such as learning,
working, and communicating.
Psychiatric disorders
may come and go,
and do not always follow
a regular pattern.
Moreover, the type, intensity,
and duration of the symptoms
vary from person to person, so this
makes it very difficult to predict
when psychiatric symptoms
will bristle
and proper functioning will decline.
Medication and
psychotherapy are often
helpful in control of symptoms.
In some of the patients,
the mental illness
may even go into remission while
in others the illness pursues.
The most common forms
of psychiatric disorders
are anxiety, major depressive
disorder, and psychosis.
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So about anxiety,
this is characterized
by non or specific worries
of fears, avoidance behavior,
increased attentional capture
by potential signs of danger,
and interpretation of
expressions, comments and events
in a negative manner.
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Then major depressive disorders
are characterized by episodes
of all-encompassing low mood,
accompanied by a low self-esteem.
Then there was a loss
of interest or pleasure
in normally enjoyable activities.
