My name is Marc Vidal.
I'm the Founding
Director of the Center
for Cancer Systems Biology at
the Dana-Farber Cancer Institute
and Professor of Genetics
at Harvard Medical School.
This presentation will discuss the
notion of interactome networks.
We will explore how complex networks
of interacting macromolecules,
or so-called interactome
underlie biological functions.
And we will summarize recent
findings that describe how
might relate to human disease.
One of the major goals of Biology
is to understand the mechanisms that
How do Mendelian mutations
lead to Mendelian disorders?
How do functional variants located
in loci found in Genome-Wide
Association Studies, or
GWAS, lead to complex traits?
And how do cancer-associated
mutations lead to tumorigenesis?
These are questions
for which we still
answers in many cases.
One set of models to explain
is based on linear cause
and effects relationships,
according to which it is relatively
convenient to directly associate
a single genotypic variation to a
single phenotypic manifestation.