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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Cell differentiation, proliferation and death
- Cell death programs in the nervous system
- PCD regulates development of the nervous system
- Similarities and differences in the PCD paradigm
- NGF withdrawal
- Conserved death mechanisms
- Boxing cell death: different death programs?
- Different death subroutines?
- Intracellular ATP level
- Common characteristics of cell death programs
- Different executioners and cell death routines
- Mechanisms of neuronal death after brain ischemia
- Calcium deregulation in brain ischemia
- Calcium homeostasis
- Calcium deregulation in excitotoxic death
- Calpains cleave NCX3 and affect calcium load
- Monitoring calpain activation in neurons
- Calpain isoform prevents lethal calcium overload
- NCX3 siRNA generates excitotoxic triggers
- NCX2 isoform prevents excitotoxicity
- Spatial control of cell death
- Death of cell bodies and axo-dendritic
- Wallerian degeneration
- Spatial control of neurodegeneration
- BoNT/C as tool to inflict synaptic damage
- BoNT/C causes neurodegeneration in neurons
- BoNT/C effects
- Distribution of mitochondrial dysfunction
- Mitochondria retain integrity
- Caspase-3 in cell soma and projections
- Distribution of neuronal clearing by microglia
- Exposure of phagocyte-recognition molecules (PS)
- Spatial control of cell death in central neurons
Topics Covered
- Cell death programs in the nervous system
- PCD
- Similarities and differences in the classical PCD paradigm between worms and vertebrates
- Conserved death mechanisms
- Apoptosis, necrosis and autophagic cell death
- Other death subroutines
- The caspases
- Intracellular ATP level
- Common characteristics of cell death programmes in vertebrates
- Different executioners and cell death routines
- Brain ischemia
- Calpain activation
- Spatial control of cell death
- Spatial control of neurodegeneration
- BoNT/C
- Mitochondrial dysfunction
- Spatial control of cell death in central neurons
Links
Series:
Categories:
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Talk Citation
Nicotera, P. (2007, October 1). Apoptosis in the nervous system [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/294/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Pierluigi Nicotera has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.