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Systems medicine and proactive P4 medicine: revolutionizing healthcare. Predictive, preventive, personalized and participatory
Published on November 4, 2014 45 min
Other Talks in the Series: Systems Biology
A systems biology approach to oncology drug development
- Dr. Birgit Schoeberl
- Merrimack Pharmaceuticals, USA
Evolutionary tradeoffs and the geometry of gene expression space
- Prof. Uri Alon
- Weizmann Institute of Science, Israel
This is a lecture on Systems Medicine and Proactive P4 medicine, Revolutionizing Health Care. Is by Lee Hood, President of the Institute for Systems Biology in Seattle, Washington.
The grand challenge for biology and medicine has always been deciphering the incredible biological complexity that are intrinsic to both. I remember early in the 1970s when I went to Caltech, puzzling over biological complexity, and beginning to think in the earliest embryonic ways about systems approaches to deal with that complexity, it was clear that we were really lacking in both technological and conceptual approaches to complexity.
It is amusing now to look over my career of some 40 years, and to see that I had actually participated in five paradigm changes in biology that dealt with complexity. The first of these paradigm changes was bringing engineering to biology. I developed five instruments that allowed us to analyze and synthesize proteins and genes. One of these was the automated DNA sequencer. And these instruments led to high throughput biology, and this, of course, ended up in creating the age of big data in biology that we're all so familiar with. The second paradigm change had to do with the fact that while inventing the automated DNA sequencer, people were beginning to consider the Human Genome Project. And I was invited to the first meeting ever, and it took us five years to persuade a very skeptical biological audience. But indeed, the Human Genome Project gave systems approaches to biology an enormous boost forward by creating a complete parts list for human genes, and by inference for the human proteins. The other advance that the automated DNA sequencer brought is I realized how to be successful we had to integrate the disciplines of engineering, computer science, chemistry, and biology. And I began then arguing that biology should create departments that are cross-disciplinary in nature, and that integrate into the biology department, the technology experts needed to invent the technologies of the future for biology. This enabled me to create the Department of Molecular Biotechnology at the University of Washington, with the generous help with Bill Gates. And that department went on over eight years to just revolutionize various aspects of genomics, and proteomics, and cell biology. It was clear that I needed to develop systems biology, again, to really deal with the complexity. And I ended up resigning from the University of Washington and creating my own institute, the Institute for Systems Biology in the year 2000. And it has focused, indeed, on developing systems science, and the allied technologies and analytic tools that were necessary for it. And very early on in this endeavor, we started applying systems biology to disease. And from that emerged the discipline of systems medicine, and ultimately, proactive P4 medicine, and I'll talk in some detail about what each of those are subsequently.