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1. Introduction
2. Select historical notes
3. Morphological forms of programmed cell death
4. Forms of cell death: type 1 - apoptosis
5. Forms of cell death: type 2 - autophagy
6. Forms of cell death: type 3 - non-lysosomal
7. Macro-autophagy interests cell death researchers
8. Autophagy: major catabolic pathways
9. What is autophagy?
10. Discovery of genes that regulate autophagy
11. How is autophagy regulated?
12. PI3K regulates growth, autophagy and apoptosis
13. Class 3 PI3K regulates autophagy
14. Ubiquitin, Atg12 and Atg8 conjugation systems
15. Where has type II autophagy been discovered?
16. Possible roles of autophagy in dying cells
17. Autophagy can prolong cell survival in dying cells
18. Autophagy can regulate cell death
19. Results of testing drosophila salivary glands
20. Effect of p35 on cell death in salivery glands
21. When are Atg genes induced?
22. Autophagy and caspases in mammary cells
23. Autophagy can promote cell death
24. Death receptor signaling
25. zVAD induces L929 cell death
26. zVAD induces autophagy in L929 cells
27. zVAD induced autophagy requires Atg7 and Atg6
28. Effects of ROS accumulation and ROS inhibitors
29. Catalase is degraded in zVAD treated cells
30. Autophagic cell death in L929 cells
31. Conclusions
32. Thanks

Topics Covered

• Morphological forms of cell death
• Why is autophagy of interest to cell death researchers?
• What is autophagy?
• Discovery of autophagy genes
• How is autophagy regulated?
• Class I PI3K signalling and Class III PI3K signalling
• Ubiquitin-like conjugation systems
• Where has autophagic cell death been observed?
• What are the possible roles of autophagy in dying cells?
• Evidence in support of autophagy prolonging cell survival
• Studies in flies and mammals suggest that both autophagy and caspases can be involved in cell death of the same cell
• Evidence in support of autophagy promoting cell death
• Inhibition of caspase-8 promotes autophagic cell death of L929 cells by autophagic degradation of catalase

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Eric Baehrecke has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.