Registration for a live webinar on 'The role of T cells in COVID from asymptomatic to severe outcomes' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
- Evolution of the Apoptotic Pathway
-
1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
-
3. The death receptor signalling pathway
- Dr. Richard Siegel
-
4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
-
5. The Bcl-2 family
- Dr. David Huang
-
6. Caspases
- Prof. Yuri Lazebnik
-
7. Natural caspase inhibitors
- Prof. Guy Salvesen
-
8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
-
10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
-
11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
-
12. p53 and apoptosis
- Prof. Moshe Oren
-
13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
-
14. Apoptosis in the immune system
- Prof. Peter Krammer
-
15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
-
16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
-
17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
-
18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
-
19. Apoptotic pathways in mammals
- Prof. Douglas Green
-
20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
-
21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
-
22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
-
23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
-
24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
-
25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- Apoptosis and other forms of PCD
- Inflammation is a beneficial, non-specific response
- Removal of apoptotic cells during development
- Involution of the mammary gland
- Remodeling of the post-lactation mammary gland
- Apoptosis (PCD)
- Efferocytosis
- How are apoptotic cells ingested?
- Mechanisms of ingestion
- Phagocytosis, macropinocytosis and efferocytosis
- Example by Yuri Miller
- Example for efferocytosis
- Dual processes for recognition and ingestion
- How are apoptotic cells recognized?
- Recognition ligands on apoptotic cells
- Phosphatidylserine
- Membrane symmetry in apoptotic cells
- Annexin V staining for PS exposure on membrane
- A dual role for calreticulin
- The collectin family of innate molecules
- The collectin family
- Collectins recognize cells and induce uptake
- Trans-activation of LRP by calreticulin
- Increase in surface calreticulin on apoptotic cells
- Calreticulin and LRP
- Co-localization of PS and calreticulin
- Apoptotic cells express a number of ligands
- Two mechanisms for ingestion of particles (cells)
- Bacterial induction of macropinocytosis
- Bystander uptake stimulated by PS
- Calreticulin promotes bystander uptake
- Bystander uptake stimulated by anti-LRP
- Modulation of efferocytosis receptors
- Receptor modulation in the uptake of cells
- Recognition of cells and foreign organisms
- The consequences of apoptotic cell recognition
- Responses to recognition of apoptotic cells (1)
- Suppression of pulmonary inflammation
- Responses to recognition of apoptotic cells (2)
- Apoptotic cell removal
- Responses to recognition of apoptotic cells (3)
- Signaling pathways in recognition
- Signaling pathways in response to recognition
- Divergent signaling responses
- How do normal viable cells avoid phagocytosis
- "Don't eat me" signals (1)
- "Don't eat me" signals (2)
- Loss of CD47 during apoptosis
- Hypothesis
- Summary
Topics Covered
- Apoptosis
- Uptake of apoptotic cells
- Specialized forms of phagocytosis
- Efferocytosis
- Anti-inflammatory and anti-immunogenic responses to apoptotic cells
- Tissue cell deletion and replacement
- Tissue homeostasis
- Autoimmunity, fibrosis and emphysema
Talk Citation
Henson, P. (2007, October 1). Phagocytosis of apoptotic cells [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/286/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Peter Henson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Phagocytosis of apoptotic cells
Published on October 1, 2007
28 min