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1. Introduction
2. Apoptosis and other forms of PCD
3. Inflammation is a beneficial, non-specific response
4. Removal of apoptotic cells during development
5. Involution of the mammary gland
6. Remodeling of the post-lactation mammary gland
7. Apoptosis (PCD)
8. Efferocytosis
9. How are apoptotic cells ingested?
10. Mechanisms of ingestion
11. Phagocytosis, macropinocytosis and efferocytosis
12. Example by Yuri Miller
13. Example for efferocytosis
14. Dual processes for recognition and ingestion
15. How are apoptotic cells recognized?
16. Recognition ligands on apoptotic cells
17. Phosphatidylserine
18. Membrane symmetry in apoptotic cells
19. Annexin V staining for PS exposure on membrane
20. A dual role for calreticulin
21. The collectin family of innate molecules
22. The collectin family
23. Collectins recognize cells and induce uptake
24. Trans-activation of LRP by calreticulin
25. Increase in surface calreticulin on apoptotic cells
26. Calreticulin and LRP
27. Co-localization of PS and calreticulin
28. Apoptotic cells express a number of ligands
29. Two mechanisms for ingestion of particles (cells)
30. Bacterial induction of macropinocytosis
31. Bystander uptake stimulated by PS
32. Calreticulin promotes bystander uptake
33. Bystander uptake stimulated by anti-LRP
34. Modulation of efferocytosis receptors
35. Receptor modulation in the uptake of cells
36. Recognition of cells and foreign organisms
37. The consequences of apoptotic cell recognition
38. Responses to recognition of apoptotic cells (1)
39. Suppression of pulmonary inflammation
40. Responses to recognition of apoptotic cells (2)
41. Apoptotic cell removal
42. Responses to recognition of apoptotic cells (3)
43. Signaling pathways in recognition
44. Signaling pathways in response to recognition
45. Divergent signaling responses
46. How do normal viable cells avoid phagocytosis
47. "Don't eat me" signals (1)
48. "Don't eat me" signals (2)
49. Loss of CD47 during apoptosis
50. Hypothesis
51. Summary

Topics Covered

• Apoptosis
• Uptake of apoptotic cells
• Specialized forms of phagocytosis
• Efferocytosis
• Anti-inflammatory and anti-immunogenic responses to apoptotic cells
• Tissue cell deletion and replacement
• Tissue homeostasis
• Autoimmunity, fibrosis and emphysema

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Peter Henson has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.