Early clinical features of Parkinson’s disease and related disorders

Published on July 1, 2014   36 min

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Other Talks in the Series: The Genetic Basis of Neurological Disorders

Hello. My name is Alastair Noyce. I'm a clinician and researcher with a particular interest in Parkinson's disease and related neurodegenerative diseases. Moreover, I'm interested in the risk factors and earliest features of disease and how these can be used to find groups of people in the earliest stages so they might be recruited to clinical trials of neuroprotective drugs. I lead a project called PREDICT-PD which aims to find people at risk of Parkinson's disease or in the earliest stages of disease, and I'll speak more about this in due course.
These are my declarations and where I receive research funding from.
Topics for discussion. This lecture will concentrate on the early clinical features of Parkinson's disease primarily and finish with discussion about the early features of Parkinson's plus conditions including multiple system atrophy and progressive supranuclear palsy. The talk will follow the slides on screen. The slides will referr to past and current research, providing references for the studies discussed. At the outset I should say this is a very large field of research, and this talk aims to provide an overview rather than be all-encompassing. In addition, this is an area of research where many questions still remain, and so I've tried to focus on those aspects for which the best evidence exists.
At the end of this lecture, you should be able to understand and discuss the general concepts around early identification of neurodegenerative disease. You should be able to list the non-motor and motor features of Parkinson's disease that are thought to occur prior to diagnosis and understand the time course that these follow, how specific each one is, along with possible neuropathological correlates. You should be able to recognize clinical features that would be unusual for early Parkinson's disease and may indicate a Parkinson plus disorder such as multiple system atrophy or PSP.

Early clinical features of Parkinson’s disease and related disorders

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