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0:00
Hello.
My name is Alastair Noyce.
I'm a clinician and researcher
with a particular interest
in Parkinson's disease and related
neurodegenerative diseases.
Moreover, I'm interested in the
risk factors and earliest features
of disease and how these can be
used to find groups of people
in the earliest stages so
they might be recruited
to clinical trials of
neuroprotective drugs.
I lead a project called PREDICT-PD
which aims to find people at risk
of Parkinson's disease or in
the earliest stages of disease,
and I'll speak more
about this in due course.
0:32
These are my declarations and where
I receive research funding from.
0:39
Topics for discussion.
This lecture will concentrate
on the early clinical features
of Parkinson's disease primarily
and finish with discussion
about the early features of
Parkinson's plus conditions
including multiple system atrophy
and progressive supranuclear palsy.
The talk will follow
the slides on screen.
The slides will referr to
past and current research,
providing references for
the studies discussed.
At the outset I should say this
is a very large field of research,
and this talk aims to
provide an overview
rather than be all-encompassing.
In addition, this is
an area of research
where many questions
still remain, and so I've
tried to focus on those aspects
for which the best evidence exists.
1:18
At the end of this
lecture, you should
be able to understand and
discuss the general concepts
around early identification
of neurodegenerative disease.
You should be able to list the
non-motor and motor features
of Parkinson's disease that are
thought to occur prior to diagnosis
and understand the time
course that these follow,
how specific each one
is, along with possible
neuropathological correlates.
You should be able to recognize
clinical features that would be
unusual for early
Parkinson's disease
and may indicate a
Parkinson plus disorder
such as multiple
system atrophy or PSP.
