• The Apoptotic Pathway in Humans
• 36 min
  1. Mitochondria and apoptosis

  • Prof. Stephen Tait
• Clinical Application of Apoptosis Research
• 31 min
  2. Targeting apoptosis pathways in cancer therapy

  • Dr. Simone Fulda
• Archived Lectures *These may not cover the latest advances in the field
• 42 min
  3. Targeting apoptosis pathways in cancer therapy

  • Dr. Irene Ghobrial
• 20 min
  4. Apoptotic pathways in mammals

  • Prof. Douglas Green
• 46 min
  5. Lysosomal cell death pathways: new possibilities for cancer therapy

  • Prof. Marja Jaattela
• 57 min
  6. Degradation of apoptotic cells

  • Prof. Shigekazu Nagata
• 61 min
  7. Signaling during engulfment: the beginnings of a good meal

  • Prof. Kodi Ravichandran
• 29 min
  8. Apoptotic cell clearance deficiencies

  • Prof. Martin Herrmann
• 46 min
  9. Caspase inhibitors in drug discovery

  • Dr. Tom O'Brien
• 28 min
  10. Mitochondria in apoptosis

  • Prof. Jean-Claude Martinou
• 52 min
  11. Apoptosis in C. elegans

  • Prof. Michael Hengartner
• 46 min
  12. Regulation of apoptosis: lessons from Drosophila and their implications for human health and disease

  • Prof. Hermann Steller
• 29 min
  13. The death receptor signalling pathway

  • Dr. Richard Siegel
• 24 min
  14. The Bcl-2 family

  • Dr. David Huang
• 43 min
  15. Caspases

  • Prof. Yuri Lazebnik
• 44 min
  16. Mechanisms of apoptosis from structural biology

  • Prof. Yigong Shi
• 64 min
  17. p53 and apoptosis

  • Prof. Moshe Oren
• 47 min
  18. The p53 family: function and molecular mechanisms

  • Prof. Gerry Melino
• 37 min
  19. Natural caspase inhibitors

  • Prof. Guy Salvesen
• 27 min
  20. TRAIL-induced apoptosis: from analysis of the death-inducing signalling complex (DISC) to clinical applicability

  • Dr. Henning Walczak
• 34 min
  21. Autophagic cell death

  • Prof. Eric Baehrecke
• 28 min
  22. Phagocytosis of apoptotic cells

  • Prof. Peter Henson
• 62 min
  23. Apoptosis in the immune system

  • Prof. Peter Krammer
• 68 min
  24. Apoptosis in the nervous system

  • Prof. Pierluigi Nicotera
• 49 min
  25. Endothelial cell apoptosis

  • Prof. Richard Kolesnick

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The concept of apoptosis
3. Developmental cues induce cell death (1)
4. Interleukin-1β converting enzyme (ICE) (1)
5. Interleukin-1β converting enzyme (ICE) (2)
6. Developmental cues induce cell death (2)
7. Cystein aspartate-cleaving proteases-caspases
8. Developmental cues induce cell death (3)
9. What's special about proteases?
10. Proteases activity is irreversible
11. Protease regulation (1)
12. Example: blood clotting cascade
13. Blood clotting pathways
14. Protease regulation (2)
15. How do caspases disassemble a cell? (1)
16. Cell disassembly is like a military operation
17. Human caspases -3 and -7
18. DNA is cleaved during apoptosis
19. How is DNA cleaved?
20. Human caspase-6
21. Caspase-6 activity
22. Effector caspases -3, -6, and -7
23. Cell death is regulated by caspase-3
24. Activation of caspases by proteolytic processing
25. Detecting ICE activity
26. ICE can be isolated by affinity labeling
27. Detecting active caspases by precursor cleavage
28. Activation of caspases -3 and -7
29. Allosteric regulation of caspases
30. Caspases can activate other caspases
31. Human caspase-9
32. Activation of caspase-9
33. Apaf-1 is a homologue of CED-4
34. Caspase-9 holoenzyme
35. Induced proximity model
36. Caspases have domains that bind other proteins
37. Blood clotting model
38. Induced activity model
39. Activation of caspase-9 via cytochrome-c
40. Cytochrome-c and caspase cascade
41. Caspase cascade and coagulation cascade
42. Human caspase-8
43. Caspase-8 recruitment and activation
44. Two cell-death pathways – caspases-8 and -9
45. Caspase inhibitors
46. Caspase inhibitor pathways
47. Intrinsic and extrinsic pathways
48. Cell death activation
49. Why do cells that die by apoptosis look alike?
50. Thank you

Topics Covered

• What makes apoptotic cells alike?
• What are caspases?
• From the worm to humans
• What is special about proteases?
• What do blood clotting and apoptosis have in common?
• How do caspases disassemble a cell?
• How do you find out if caspases are active?
• How are caspases activated?
• What is left to learn?

Links

Series:

• Apoptosis

Categories:

• Cell Biology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007
• Archived on May 28, 2025

Financial Disclosures

• Prof. Yuri Lazebnik has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.