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- Evolution of the Apoptotic Pathway
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1. Apoptosis in C. elegans
- Prof. Michael Hengartner
- The Apoptotic Pathway in Humans
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3. The death receptor signalling pathway
- Dr. Richard Siegel
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4. Mitochondria and apoptosis
- Prof. Stephen Tait
- Apoptosis Molecules
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5. The Bcl-2 family
- Dr. David Huang
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6. Caspases
- Prof. Yuri Lazebnik
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7. Natural caspase inhibitors
- Prof. Guy Salvesen
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8. Mechanisms of apoptosis from structural biology
- Prof. Yigong Shi
- Clearance of Apoptotic Cells
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10. Phagocytosis of apoptotic cells
- Prof. Peter Henson
- Non-Apoptotic Cell Death Programs
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11. Autophagic cell death
- Prof. Eric Baehrecke
- Apoptosis and Disease
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12. p53 and apoptosis
- Prof. Moshe Oren
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13. The p53 family: function and molecular mechanisms
- Prof. Gerry Melino
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14. Apoptosis in the immune system
- Prof. Peter Krammer
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15. Apoptosis in the nervous system
- Prof. Pierluigi Nicotera
- Clinical Application of Apoptosis Research
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16. Endothelial cell apoptosis
- Prof. Richard Kolesnick
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17. Targeting apoptosis pathways in cancer therapy
- Dr. Simone Fulda
- Archived Lectures *These may not cover the latest advances in the field
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18. Targeting apoptosis pathways in cancer therapy
- Dr. Irene Ghobrial
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19. Apoptotic pathways in mammals
- Prof. Douglas Green
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20. Lysosomal cell death pathways: new possibilities for cancer therapy
- Prof. Marja Jaattela
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21. Degradation of apoptotic cells
- Prof. Shigekazu Nagata
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22. Signaling during engulfment: the beginnings of a good meal
- Prof. Kodi Ravichandran
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23. Apoptotic cell clearance deficiencies
- Prof. Martin Herrmann
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24. Caspase inhibitors in drug discovery
- Dr. Tom O'Brien
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25. Mitochondria in apoptosis
- Prof. Jean-Claude Martinou
Printable Handouts
Navigable Slide Index
- Introduction
- The concept of apoptosis
- Developmental cues induce cell death (1)
- Interleukin-1β converting enzyme (ICE) (1)
- Interleukin-1β converting enzyme (ICE) (2)
- Developmental cues induce cell death (2)
- Cystein aspartate-cleaving proteases-caspases
- Developmental cues induce cell death (3)
- What's special about proteases?
- Proteases activity is irreversible
- Protease regulation (1)
- Example: blood clotting cascade
- Blood clotting pathways
- Protease regulation (2)
- How do caspases disassemble a cell? (1)
- Cell disassembly is like a military operation
- Human caspases -3 and -7
- DNA is cleaved during apoptosis
- How is DNA cleaved?
- Human caspase-6
- Caspase-6 activity
- Effector caspases -3, -6, and -7
- Cell death is regulated by caspase-3
- Activation of caspases by proteolytic processing
- Detecting ICE activity
- ICE can be isolated by affinity labeling
- Detecting active caspases by precursor cleavage
- Activation of caspases -3 and -7
- Allosteric regulation of caspases
- Caspases can activate other caspases
- Human caspase-9
- Activation of caspase-9
- Apaf-1 is a homologue of CED-4
- Caspase-9 holoenzyme
- Induced proximity model
- Caspases have domains that bind other proteins
- Blood clotting model
- Induced activity model
- Activation of caspase-9 via cytochrome-c
- Cytochrome-c and caspase cascade
- Caspase cascade and coagulation cascade
- Human caspase-8
- Caspase-8 recruitment and activation
- Two cell-death pathways – caspases-8 and -9
- Caspase inhibitors
- Caspase inhibitor pathways
- Intrinsic and extrinsic pathways
- Cell death activation
- Why do cells that die by apoptosis look alike?
- Thank you
Topics Covered
- What makes apoptotic cells alike?
- What are caspases?
- From the worm to humans
- What is special about proteases?
- What do blood clotting and apoptosis have in common?
- How do caspases disassemble a cell?
- How do you find out if caspases are active?
- How are caspases activated?
- What is left to learn?
Talk Citation
Lazebnik, Y. (2007, October 1). Caspases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved May 8, 2024, from https://hstalks.com/bs/282/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Yuri Lazebnik has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.