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Printable Handouts
Navigable Slide Index
- Introduction
- Apoptosis: cell suicide
- bcl-2 gene overexpressed in follicular lymphoma
- Cancer genetics reveal the first apoptosis regulator
- Phenotype of bcl-2 -/- mice
- Apoptosis in C. elegans is controlled by 4 genes
- CED-9 inhibits cell death
- EGL-1 is a BH3-only protein
- Evolutionarily conserved pathways to cell death
- How cell death initiates
- EGL-1 is a BH3-only protein
- Mammals bear multiple BH3-only proteins
- Does Bim antagonize Bcl-2?
- Bcl-2 promotes and Bim antagonizes cell survival
- A general model
- Loss of Bim compansates for loss of Bcl-2
- BH3-only proteins initiate apoptosis
- BH3-only proteins monitor cellular well-being
- Distinct but converging pathways to apoptosis
- Binding surface formed by BH1, BH2, BH3
- How selective are BH3-only proteins?
- BH3-only proteins fall into distinct subsets
- Bad and Noxa co-operate functionally
- Both subsets must be neutralized for killing
- How do pro-survival Bcl-2 proteins keep cells alive?
- Killing by BH3-only proteins require Bax and Bak
- Bax, Bak: the other class of Bcl-2-related proteins
- Some BH3-only proteins directly activate Bax/Bak
- Apoptosis in the absence of putative activators
- BH3-only proteins activate Bax/Bak indirectly
- Bak sequestered in healthy cells by Mcl-1, Bcl-xL
- Both Mcl-1 & Bcl-xL need to be neutralized
- Bcl-2 has no direct role in controlling Bak
- How is Bax regulated?
- Are there other steps required for activation?
- Some other outstanding questions
- Do the pro-survival proteins have other functions?
- Interactions determine cell survival
- Deregulation of apoptosis causes disease
- Acknowledgements
Topics Covered
- Apoptosis
- Discovery of Bcl-2
- Cell death in worms
- Evolutionarily conserved pathways to cell death
- How cell death initiates
- BH3-only proteins
- Control of BH3- only proteins
- Promiscuous and selective BH3-only proteins
- Diverse Bcl-2 prosurvival proteins must be neutralized for apoptosis
- Pro-survival Bcl-2 proteins restrain Bax and Bak
- Apoptosis in the absence of "activator" BH3-only proteins
- BH3-only proteins activate Bax and Bak indirectly
- Control of Bak
- Outstanding questions
Links
Series:
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Talk Citation
Huang, D. (2007, October 1). The Bcl-2 family [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 6, 2024, from https://doi.org/10.69645/DJYC1587.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. David Huang has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.