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1. Introduction
2. Review
3. Apoptosis signaling pathways
4. Responses triggered by TNF-family receptors
5. TNF-SF structure-function: TNF ligands
6. TNF receptors: extracellular domains
7. TNF ligand: receptor binding
8. Death domain
9. Apoptosis triggered through recruitment of DISC
10. Regulation of early death receptor signaling (1)
11. Preassociation of fas and other TNFRs
12. TNF-SF receptors without death domain
13. Spectrum of receptors in the TNF-R superfamily
14. TNF receptor dual signaling : the 2 complex model
15. Alternative caspase-independent cell death
16. Elimination of restimulted T cells is clonotypic
17. TCR stimulation sensitizes cells to die via fas
18. Lipid rafts in antigen receptor signal transduction
19. TCR restimulation results in relocalization of fas
20. Relocalization increases sensitivity to apoptosis
21. Fas vs. TNFR1
22. Regulation of early death receptor signaling (2)
23. Fas engagement induces rapid receptor clustering
24. Formation of SPOTS is dependent on Fas / FADD
25. Two phases of Fas receptor redistribution
26. SPOTS localization and enhancement
27. SPOTS: platforms for Fas signaling
28. The Fas pathway
29. The death receptor signaling pathway
30. Death receptors in T cells homeostasis
31. Fas (TNFRSF 6): negative regulation
32. TNF: inflammation and enhancement of immunity
33. DR3: a T cell costimulator?
34. TRAIL: cancer and innate immunity
35. Other TNF family recepotrs with a death domain
36. ALPS: genetic defects in the Fas pathway
37. Two ALPS mutation interference mechanisms
38. Relationship between Fas mutations and disease
39. TRAP syndrome
40. TRAPS-associated TNFR1 mutations
41. Sources for further reading

Topics Covered

• Death Receptors and ligands
• Structural features
• receptor signalling complexes
• Regulation of death receptor signalling
• Receptor oligomerization and internalization
• Genetic diseases affecting death receptors
• Manipulating death receptors with therapeutics

Links

Series:

• Apoptosis

Categories:

• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Dr. Richard Siegel has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.