Human hepatocyte isolation for clinical transplantation

Published on March 5, 2014   43 min
0:00
Hello. I'm Stephen Strom. I'm a Torsten och Ragnar Soderberg Professor of Cell Transplantation Regenerative Medicine at the Department of Laboratory and Medicine, Karolinska Institute in the Division of Pathology. I'm going to talk today about the Human Hepatocyte Isolation for Clinical Transplants. Our group is the first to transplant human hepatocytes into patients with liver disease in America, and my laboratory was the first one to be approved by the FDA for isolation of hepatocytes for clinical transplants so we'd like to share this experience with you. We've collected about 2,000 livers for hepatocyte isolation, so we have some considerable experience in this area.
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Although I don't believe there's any conflict of interest, I put this slide in there. I am a stockholder in Stemnion, which is a stem cell company interested in placental stem cells and Yecuris, which is a company interested in making mice with humanized livers for drug discovery and drug metabolism research. But none of the products from Yecuris or Stemnion are used in any of these slides I'm going to present today. So what we're interested in is really this field called hepatocyte transplantation, and this is a cellular therapy for liver disease.
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Human hepatocyte isolation for clinical transplantation

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