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In this talk, we turn
our attention to
precision medicine,
framing our discussion around
the foundations and advances
in precision medicine,
focusing on how
individualized care is
achieved through genomic
and molecular profiling.
We will discuss the critical
role of biomarkers and
pharmacogenomic
testing in guiding
therapy choices and maximizing
treatment efficacy.
Examples from
oncology, cardiology,
and rare diseases
will illustrate
the expanding impact
of precision medicine.
Finally, we will address
the ongoing challenges
such as variant
interpretation, accessibility,
and ethical considerations
and highlight
future directions involving
artificial intelligence
and multiomix integration.
In this lecture, we explore
the foundations and advances
in precision medicine,
a field aiming to tailor
healthcare at the
individual level.
Unlike traditional approaches,
precision medicine uses
a patient's biological
and genetic profile
to guide risk assessment,
prevention, diagnosis,
and therapy.
With affordable
genomic sequencing,
proteomics, and
molecular diagnostics,
clinicians can
design interventions
that reflect human and
disease diversity,
maximizing efficacy and
minimizing side effects.
Central to precision
medicine is using
genomic and molecular profiling
of patients and their diseases.
Advanced sequencing tools can
characterize not only a
patient's inherited
germ line DNA,
but also somatic mutations in
diseased tissues like tumors.
Technologies such as whole xome
