G-Protein coupled receptors in drug discovery

Published on February 4, 2014   42 min

Other Talks in the Series: Small Molecule Drug Discovery

Hello, and welcome to the Henry Stewart lecture series on Small Molecule Drug Discovery. My name is Mark Wigglesworth, and I'm the Director at the Global High Throughput Screening organization within AstraZeneca. Today I have a presentation for you on, G-Protein Coupled Receptors in Drug Discovery. I've had a long interest in both screening and in G-protein coupled receptors. I hope the presentation that follows will give you some insight into both and how their impacting to discovery both today and in the future.
I'm going to start with some information which I'm sure you're all already aware of, and that is GPCRs, the size of the super family, and that this is actually a very significant opportunity for all of us that work within drug discovery. The graph that you're looking at on this slide simply shows the number of proteins targets within some major target super families. And GPCR showed, on this graph, as having around 800 family members, by far the largest single protein class that are successfully targeted by drugs today.