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- Evolutionary Perspectives
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1. Antibiotic resistance: a mechanistic overview
- Dr. Neil Woodford
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2. Mutation
- Prof. Stephen Gillespie
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3. Fitness in antibiotic resistant bacteria
- Prof. Stephen Gillespie
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4. Fitness and compensation
- Dr. Sébastian Gagneux
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5. Antibiotic resistance and the supragenome hypothesis
- Dr. Bambos Charalambous
- Epidemiology and Clinical Impact
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6. Methicillin resistant S. aureus and other resistances
- Prof. Mark Enright
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7. Risk factors for antibiotic resistance in Streptococcus pneumoniae
- Prof. Keith Klugman
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8. Beta-lactamases: clinical impact and epidemiology
- Prof. Sebastian Amyes
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9. Glycopeptide-resistant enterococci
- Dr. Neil Woodford
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10. Drug resistant tuberculosis: biology, epidemiology and control
- Dr. Christopher Dye
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11. Antiretroviral drug resistance
- Prof. Deenan Pillay
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12. Malaria - changing paradigms
- Dr. Janet Cox-Singh
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13. Advances in mode of action of antimalarials and resistance mechanisms 1
- Prof. David Warhurst
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14. Advances in mode of action of antimalarials and resistance mechanisms 2
- Prof. David Warhurst
- Diagnosis and Surveillance of Resistance
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15. Conventional and automated diagnostic methods
- Dr. Alan Johnson
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16. National and international surveillance of antibiotic resistance 1
- Prof. David Livermore
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17. National and international surveillance of antibiotic resistance 2
- Prof. David Livermore
- Controlling Antibiotic Resistance
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18. Controlling antibiotic resistance in the hospital environment
- Dr. Ian Eltringham
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19. Controlling antibiotic resistance in the community
- Dr. Peter Wilson
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20. Public policy to reduce antibiotic resistance
- Dr. Niels Frimodt-Møller
- The Antibiotic Resistance Future
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21. Overcoming resistance through novel drug targets
- Prof. Anthony Coates
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22. Medicinal chemistry strategies in combating antibiotic resistance
- Dr. Geoffrey Coxon
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23. Teixobactin kills pathogens without detectable resistance
- Prof. Kim Lewis
- Archived Lectures *These may not cover the latest advances in the field
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24. Molecular diagnosis of antibiotic resistance
- Dr. Tim McHugh
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25. Introduction to malaria
- Prof. David Warhurst
Printable Handouts
Navigable Slide Index
- Introduction
- Drug resistance mechanisms
- Chloroquine-resistance in falciparum malaria
- Chloroquine-resistance caused raised fatality
- Resistance mechanisms
- PfCRT (coded on chromosome 7)
- PfCRT based on structure of E. coli 1PW5
- The ancestor of PfCRT may be a thiol carrier CLT
- Activity of D-AQ in CQ-R
- AQ selected the SVMNT CQ-resistance variant
- Can CQ become useful once more?
- Resistance to artemisinin
- Mutations in Pgh-1
- PgH-1
- Modeled PgH-1 transporter
- Mouse PgH-1 transporter model
- Mutated protein pumps more HF into the DV
- Resistance mechanisms summary
- Rationale for ACT
- UBP-1 changes associated with drug-resistance
- Piperaquine and dihydroartemisinin combination
- Life cycle stage as drug target - summary (1)
- Life cycle stage as drug target - summary (2)
- Controlling the spread of resistance
- Approach to urgent treatment for severe malaria
- Intermittent preventive treatment: IPT
Topics Covered
- Drug resistance mechanisms
- Chloroquine-resistance in falciparum malaria
- PfCRT protein -Resistance to artemisinin
- PgH-1
- Rationale for Artemisinin combination therapy
- Controlling the spread of resistance
- Approach to urgent treatment for severe malaria
- Intermittent preventive treatment
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Warhurst, D. (2013, November 6). Advances in mode of action of antimalarials and resistance mechanisms 2 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 26, 2024, from https://hstalks.com/bs/2691/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. David Warhurst has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Advances in mode of action of antimalarials and resistance mechanisms 2
Published on November 6, 2013
38 min
A selection of talks on Clinical Practice
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