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Navigable Slide Index

1. Introduction
2. Life cycle stage as drug target
3. Malaria parasite in red blood cell
4. Action of antiplasmodial drugs
5. Chloroquine base is trapped in acidic DV
6. Targets other than DV
7. Sdx and Pyr targets in the folate synthesis cycle
8. Resistance to sulfadoxine and pyrimethamine
9. Mitochondrial compartment
10. CoQ8 and atovaquone similarity
11. Cytochrome B wild type vs. mutant
12. Apicoplast
13. Cultured pre-erythrocytic schizont of P. berghei
14. CQ, QN, mefloquine, artemisinin & analogues
15. Sweet wormwood (Artemisia annua) (1)
16. Sweet wormwood (Artemisia annua) (2)
17. Artemisinin structure and metabolism
18. Artemisinin mode of action
19. Evidence for drug activation

Topics Covered

• Life cycle stage as drug target
• Action of antiplasmodial drugs
• The digestive vacuole
• Resistance to sulfadoxine and pyrimethamine
• Artemisinin mode of action

Links

Series:

• Antibiotic Resistance

Categories:

• Clinical Practice
• Microbiology
• Pharmaceutical Sciences

Therapeutic Areas:

• Infectious Diseases

Talk Citation

Warhurst, D. (2013, November 6). Advances in mode of action of antimalarials and resistance mechanisms 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/RJQD2828.
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Publication History

• Published on November 6, 2013

Financial Disclosures

• Prof. David Warhurst has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.