• View the Talks
• 50 min
  1. Where the thoughts dwell: history of neuroscience and introduction into neuroglia

  • Prof. Alexei Verkhratsky
• 35 min
  2. Astrocytes: definition, appearance and general physiology 1

  • Prof. Alexei Verkhratsky
• 30 min
  3. Astrocytes: definition, appearance and general physiology 2

  • Prof. Alexei Verkhratsky
• 39 min
  4. Glial calcium signalling

  • Prof. Alexei Verkhratsky
• 33 min
  5. Astroglial calcium signalling: what it could tell us

  • Prof. Dmitri Rusakov
• 42 min
  6. Neuronal-glial chemical transmission mediated by glutamate and ATP

  • Prof. Alexei Verkhratsky
• 27 min
  7. Energy and amino acid neurotransmitter metabolism in astrocytes

  • Prof. Helle Waagepetersen
• 49 min
  8. Mechanisms of glutamate release from astrocytes

  • Prof. Vladimir Parpura
• 37 min
  9. Cannabinoid type 1 receptors in astrocytes

  • Prof. Giovanni Marsicano
• 34 min
  10. Neuronal-glial anatomical plasticity in the hypothalamus

  • Dr. Stéphane H.R. Oliet
• 25 min
  11. General physiology of oligodendrocytes

  • Prof. Arthur M. Butt
• 35 min
  12. Neuropathology of microglia and oligodendrocytes

  • Prof. Arthur M. Butt
• 38 min
  13. Oligodendroglia/MCT1 are an unexpected contributor to CNS toxicity/neurodegeneration

  • Prof. Jeffrey D. Rothstein
• 41 min
  14. Physiology and pathophysiology of microglia

  • Prof. Dr. Uwe-Karsten Hanisch
• 39 min
  15. Properties of regulated exocytosis in astrocytes

  • Prof. Robert Zorec
• 49 min
  16. Exocytosis and gliocrine astroglia

  • Prof. Robert Zorec
• 37 min
  17. Noradrenergic hypothesis of neurodegeneration and astroglia

  • Prof. Robert Zorec
• 45 min
  18. Principles of astrogliopathology: from reactivity to atrophy and degeneration

  • Prof. Alexei Verkhratsky
• 23 min
  19. Regulation of synaptic plasticity by astroglia

  • Prof. Dmitri Rusakov
• 48 min
  20. Enteric glia: the glue of the enteric nervous system

  • Dr. Keith A. Sharkey
• 38 min
  21. Purinergic neuron-to-glia signaling in the enteric nervous system

  • Dr. Brian D. Gulbransen
• 43 min
  22. Astrocytes and Alexander disease: the first - but not last - primary astrocyte disease

  • Prof. Albee Messing
• 45 min
  23. Vesicular release of glutamate mediates bidirectional signaling between astrocytes and neurons

  • Prof. Vladimir Parpura
• 43 min
  24. The impact of astrocyte mitochondrial ATP production on neuroprotection after stroke

  • Prof. James Lechleiter
• 33 min
  25. Hepatic encephalopathy in cirrhosis: a disorder of glial-neuronal signalling

  • Prof. Roger F. Butterworth
• 33 min
  26. Hepatic encephalopathy in acute liver failure: a primary neurogliopathy

  • Prof. Roger F. Butterworth
• 37 min
  27. Bi-directional communication at the neurovascular unit: implications for neuronal function

  • Prof. Jessica A. Filosa
• 51 min
  28. Astrocyte reactivity

  • Prof. Michael Sofroniew
• 36 min
  29. Roles of microglia in the healthy brain

  • Dr. Marie-Ève Tremblay
• Archived Lectures *These may not cover the latest advances in the field
• 44 min
  30. Astroglia in neuropathology

  • Prof. Alexei Verkhratsky
• 44 min
  31. Cell biology and physiology of astroglia

  • Prof. Alexei Verkhratsky
• 29 min
  32. General physiology of oligodendrocytes and Schwann cells

  • Prof. Arthur M. Butt

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Classification of hepatic encephalopathy
3. Hepatic encephalopathy in cirrhosis (1)
4. Hepatic encephalopathy in cirrhosis (2)
5. Transjugular intrahepatic portosystemic shunt
6. Hepatic encephalopathy post-TIPS
7. Survival in TIPS patients as a function of HE grade
8. Neuropathology of HE in chronic liver failure
9. Pathogenesis of HE in cirrhosis: neuroimaging (1)
10. T1-weighted MRI due to manganese deposition
11. Cirrhosis-related Parkinsonism: MRI findings
12. Cirrhosis-related Parkinsonism
13. Pathogenesis of HE in cirrhosis: neuroimaging (2)
14. PET studies in cirrhosis (1)
15. Deactivation of anterior cingulate cortex
16. NCT-B test
17. PET studies in cirrhosis (2)
18. 13NH3 PET images of brain in a cirrhotic patient
19. Neuroinflammation and HE in cirrhosis
20. SIRS in cirrhosis
21. Circulating TNF alpha in cirrhotic patients
22. Serum TNF alpha in HE grade improvement
23. Microglial activation in biliary cirrhosis model
24. Translocator protein and HE in cirrhosis
25. Translocator protein
26. Translocator protein complex
27. IBP - a key subunit of translocator protein
28. Increased translocator protein sites in HE brain
29. PET imaging using the translocator protein ligand
30. Translocator protein activation
31. Modulatory site for neurosteroids
32. GABA-A receptor activation by neurosteroids
33. Allopregnanolone levels and hepatic coma
34. Prevention and treatment of HE in cirrhosis (1)
35. Treatment of precipitating factors
36. Nutrition
37. Non-metabolizeable disaccharides
38. Antibiotics
39. L-ornithine L-aspartate lowers ammonia levels
40. Summary
41. Prevention and treatment of HE in cirrhosis (2)
42. Flumazenil in HE: results of a meta-analysis
43. Emerging new therapeutic approaches
44. Take home messages (1)
45. Take home messages (2)
46. Acknowledgements

Topics Covered

• Classification of hepatic encephalopathy
• Hepatic encephalopathy in cirrhosis
• Transjugular intrahepatic portosystemic shunt (TIPS)
• Hepatic encephalopathy post-TIPS
• Neuropathology of hepatic encephalopathy in chronic liver failure
• Cirrhosis-related Parkinsonism
• PET studies in cirrhosis
• Neuroinflammation and hepatic encephalopathy in cirrhosis
• Systemic inflammatory response syndrome (SIRS) in cirrhosis
• Translocator protein and hepatic encephalopathy in cirrhosis
• Modulatory site for neurosteroids
• Prevention and treatment of hepatic encephalopathy in cirrhosis
• Emerging new therapeutic approaches

Links

Series:

• Physiology and Pathophysiology of Neuroglia

Categories:

• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on November 5, 2013

Financial Disclosures

• Prof. Roger F. Butterworth, Speaker’s Bureau: Merz Pharmaceuticals, Frankfurt, Germany.