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Influence of neurotransmitter receptor variants on interactions with psychotropic drugs

Published on October 1, 2007 Updated on December 2, 2014   25 min

A selection of talks on Pharmaceutical Sciences

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This talk, we focus on influence of genetic variants in neurotransmitter receptors on the response with treatment with psychotropic drugs.
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The talk is divided into five parts, starting with a brief introduction. A second part is dedicated to genetic variants in dopamine receptors and transporters and the influence on treatment response. The third chapter summarizes the effect of genetic variants in the serotonergic system, followed by a chapter on genetic variants in other neurotransmitter systems and their influence on clinical outcome.
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Introduction-- The mainstay treatment
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of severe mental disorders, such as schizophrenia and bipolar disorders, is the use of psychotropic drugs. However, not all patients respond to treatment. 30 to 50% of treated patients fail to respond. And about 60 to 70% of treated patients develop long lasting and severe side effects, which can be life threatening.
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The causes of treatment variability are a combination of genetic, environmental, and clinical factors. A limited number of family and genetic studies support the contribution of genetic factors to the variability in treatment response to psychotropic treatment, although no extensive treatment study has been performed to quantify their contribution. There is also evidence suggesting that environmental and clinical factors influence treatment response, factors such as smoking, food, plasma levels, therapeutic doses, concomitant treatment, especially when patients are treated with several drug substrates for the same metabolic enzyme. Ethnicity, age and gender of the patient, the severity of illness, all have been suggested to contribute to treatment response, however, none of mentioned clinical and environmental factors can reliably predict treatment response. And it is thought that interaction between genetic and non-genetic factors results in treatment variability.

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Influence of neurotransmitter receptor variants on interactions with psychotropic drugs

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