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Navigable Slide Index

1. Introduction
2. Systems biology and "omics" (1)
3. Cardiovascular continuum
4. Proteomics (1)
5. Proteomics (2)
6. Publications on proteomics
7. Rationale for proteomic studies
8. Samples
9. Platforms
10. LC-MS/MS platform
11. Technical challenges
12. Post translational modifications
13. Unravelling pathophysiology (1)
14. Epicardial fat
15. Unravelling pathophysiology (2)
16. Western blot and IHC
17. NBT assay of ROS
18. Biomarker of disease
19. Urinary proteomics (CE/MS platform)
20. Why urine?
21. CE/MS platform
22. Methods (1)
23. Methods (2)
24. Patients
25. 239 biomarker panel
26. Identification of proteins
27. Single marker
28. Two markers
29. Three markers
30. Better discrimination with more markers
31. Effect of drug therapy
32. Pre-eclampsia (1)
33. Pre-eclampsia (2)
34. Normal pregnancy
35. Maternal risk factors
36. Study design
37. Clinical characteristics
38. Pregnancy specific proteomic biomarkers
39. Pre-eclampsia specific biomarkers (1)
40. Pre-eclampsia specific biomarkers (2)
41. Change in classification factor
42. Sequencing
43. Plasma proteome
44. Pre-eclampsia and cardiovascular risk
45. Serum proteomics (1)
46. Serum proteomics (2)
47. Urinary proteomics (SELDI) (1)
48. Urinary proteomics (SELDI) (2)
49. Organ damage
50. Stroke (1)
51. Stroke (2)
52. Heart failure
53. Biomarker of risk
54. Chronic kidney disease pattern
55. Diabetic nephropathy (1)
56. Diabetic nephropathy (2)
57. Study flow chart
58. Integrating "omics" data
59. Systems biology and "omics" (2)
60. Summary and conclusions
61. Acknowledgements

Topics Covered

• Systems biology
• Definition of proteomics
• Proteomics: rationale and practical aspects
• Proteomics in cardiovascular pathophysiology
• Proteomics to detect biomarkers of cardiovascular disease
• Urinary proteomics using capillary electrophoresis / mass spectrometry
• Proteomics of coronary artery disease
• Proteomics of pre-eclampsia
• Proteomics of other cardiovascular diseases: stroke, heart failure, diabetic nephropathy

Links

Series:

• Clinical Proteomics

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Methods

Therapeutic Areas:

• Cardiovascular & Metabolic

Talk Citation

Delles, C. (2013, November 5). Proteomics in cardiovascular disease: clinical considerations [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved June 6, 2023, from https://hstalks.com/bs/2657/.
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Publication History

• Published on November 5, 2013

Financial Disclosures

• Dr. Christian Delles has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.