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- Introduction
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16 min
1. Psychopharmacology: structural aspects of the brain- Prof. Brian Leonard
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66 min
2. The nature of chemical neurotransmission- Prof. Brian Leonard
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28 min
3. Psychotropic drugs- Prof. Brian Leonard
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26 min
4. Psychopharmacology of anxiety disorders- Prof. Brian Leonard
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35 min
5. Psychopharmacology of depression- Prof. Brian Leonard
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48 min
6. Psychopharmacology of mania and schizophrenia- Prof. Brian Leonard
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45 min
7. The role of stress and immune system in psychiatric disorders- Prof. Brian Leonard
- Introduction to Genetic Investigations of Complex Traits
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39 min
- Genetics and Pharmacokinetics of Psychotropic Drugs
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34 min
9. Genetics of phase I enzymes- Prof. Aiming Yu
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36 min
10. Phase II metabolism- Prof. Ann Daly
- Genetics and Pharmacodynamics of Psychotropic Drugs
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25 min
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25 min
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51 min
13. Pharmacogenetics of antidepressants- Prof. Alessandro Serretti
- Clinical Applications of Psychopharmacogenetics
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41 min
14. Of genes and drugs: genetic determinants of adverse drug reactions- Dr. Mario Masellis
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35 min
15. Cocaine and amphetamine addiction genetics- Dr. Gerome Breen
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29 min
- Archived Lectures *These may not cover the latest advances in the field
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47 min
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37 min
18. Genetic determinants of metabolism: clinical applications in psychiatry- Prof. Julia Stingl (formerly Kirchheiner)
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36 min
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47 min
20. Genetic polymorphisms influencing response to lithium- Prof. Alessandro Serretti
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28 min
21. Genetic determinants of antipsychotic-induced weight gain- Prof. Gavin Reynolds
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59 min
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50 min
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37 min
24. Genetic determinants of agranulocytosis- Dr. Michael Dettling
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52 min
25. Genetic polymorphisms influencing the response of antidepressants- Prof. Alessandro Serretti
Printable Handouts
Navigable Slide Index
- Introduction
- Pharmacogenetic phenotypes
- Enzymes assays for pharmacokinetics
- Polymorphism to DME activity: CYP2D6
- Polymorphism to DME activity: CYP2C9
- CYP2C9 genotypes in warfarin patients
- Pharmacogenetics: the key markers to test for
- Typical process for genotyping samples
- Rapid sample analysis
- Methods for sequence analysis
- Homogeneous PCR assays
- Complex probe technologies
- HyBeacon probes
- HyBeacon assays: SNP discrimination
- Differential probe hybridisation
- Development of CYP2D6*4 assay
- Analysis of CYP2D6*4 SNP
- Development of a factor V Leiden assay
- Analysis of factor V Leiden
- Sickle cell anaemia
- HyBeacon multiplex potential
- The secret is in the dribble
- Direct sample analysis
- Point-of-care diagnostics
- Automated sample analysis
- Traditional vs point-of-care diagnostics
- Pharmacogenetics: avoiding adverse drug reactions
- Link DME activity to prescription: CYP2D6
- Personalising medication
- Applications - consent and ethics
- The future
Topics Covered
- Key pharmacogenetic targets
- Minimizing laboratory processing
- Homogenous reactions and DNA probes
- Rapid and simple allele discrimination
- Point of care
Links
Series:
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Talk Citation
Debenham, P. (2007, October 1). Rapid methods for the genetic determination of pharmacokinetic status [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/NTDH2741.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Paul Debenham has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Rapid methods for the genetic determination of pharmacokinetic status
A selection of talks on Methods
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