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- An Overview of Drug Discovery and Development
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78 min
1. Rules and filters and their impact on success in chemical biology and drug discovery- Dr. Christopher Lipinski
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37 min
2. Where did drugs come from?- Dr. David Swinney
- Target Selection in Early Stage Drug Discovery
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42 min
3. G-Protein coupled receptors in drug discovery- Dr. Mark Wigglesworth
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42 min
4. Enzymology in drug discovery 1- Prof. Robert Copeland
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66 min
5. Enzymology in drug discovery 2- Prof. Robert Copeland
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41 min
6. Inhibiting protein-protein interactions 1- Dr. Adrian Whitty
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35 min
7. Inhibiting protein-protein interactions 2- Dr. Adrian Whitty
- Key Drug Discovery Challenges in Major Therapeutic Areas
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64 min
8. Current trends in antiviral drug development- Prof. Dr. Erik De Clercq
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27 min
9. The challenge of developing drugs for neglected parasitic diseases- Prof. James Mckerrow
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55 min
10. Is there a role for academia in drug discovery- Dr. Adrian J. Ivinson
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31 min
11. Key drug discovery challenges in cardiovascular medicine- Dr. Dan Swerdlow
- Dr. Michael V. Holmes
- Methods of Hit Identification
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46 min
12. Fragment-based lead discovery- Dr. Daniel A. Erlanson
- Medicinal Chemistry and SAR
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53 min
13. Hit to lead- Dr. Michael Rafferty
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37 min
14. Prodrug strategies to overcome problems in drug therapy- Prof. Jarkko Rautio
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40 min
15. Deep ocean microorganisms yield mechanistically-novel anticancer agents- Prof. William Fenical
- From Lead to Drug
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25 min
16. Biomarkers in drug development: potential use and challenges- Dr. Abdel-Bassett Halim
- Case Studies in Drug Discovery
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35 min
17. Current concepts for the management of patients with osteoporosis- Dr. Michael Lewiecki
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35 min
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36 min
19. Teixobactin kills pathogens without detectable resistance- Prof. Kim Lewis
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20 min
20. Discovery of schizophrenia drug targets from DISC1 mechanisms- Prof. Atsushi Kamiya
- Archived Lectures *These may not cover the latest advances in the field
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46 min
21. CNS-drug design- Prof. Quentin Smith
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38 min
22. Imatinib as a paradigm of targeted cancer therapies- Prof. Brian Druker
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44 min
23. New and emerging treatments for osteoporosis- Dr. Michael Lewiecki
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38 min
24. Prodrugs and drug delivery- Prof. Jarkko Rautio
Printable Handouts
Navigable Slide Index
- Introduction
- Topics
- Stages of drug development
- Attrition in drug development
- Increased drug development cost - Eroom's law
- Drug development strategies are unsustainable
- Number of hits for biomarkers-related publications
- How Pharaohs detected pregnancy
- Biomarkers in drug development
- PG biomarkers in FDA-approved drug labels
- Personalized medicine: potential value & benefits
- Vemurafenib (Zelboraf)/BRAF mutation test
- How can a biomarker be useful?
- Expectations from biomarker results
- Challenges
- LDL-C and HDL-C predict CHD
- Inadequate understanding of biology
- Intra-tumor heterogeneity
- Can we have right tissue quantity and quality?
- The pursuit of traceability
- Blood hemoglobin: standardized assays
- Perceived level of confidence in a laboratory test
- Regulated molecular Dx
- LDH on different platforms
- Within-lab/within-platform reagent lot-to-lot change
- Regulated biomarker assays
- Different platforms: ALP (1)
- Different platforms: ALP (2)
- The case of LDL-C
- LDL-C detection using different methods
- PT as a surrogate for appropriate anticoagulation
- PT results analyzed in different labs
- Conclusion
- How to mitigate analytical challenges?
- Concluding remarks
Topics Covered
- Biomarkers in drug development
- Classes of biomarkers
- Crisis in pharmaceutical development
- Potential value of biomarkers and personalized medicine to enhance probability of success
- Challenges (biology, pre-analytical, analytical)
- Possible mitigation
Talk Citation
Halim, A. (2022, February 24). Biomarkers in drug development: potential use and challenges [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 27, 2024, from https://doi.org/10.69645/IGAK6703.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Abdel-Bassett Halim has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Biomarkers in drug development: potential use and challenges
A selection of talks on Pharmaceutical Sciences
Transcript
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