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Biomarkers in drug development: potential use and challenges

Published on September 23, 2013 Reviewed on February 24, 2022   25 min

A selection of talks on Pharmaceutical Sciences

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0:00
Hello. This is Abdel Halim, Director and Function Lead of Clinical Biomarkers at Daiichi-Sankyo Global Pharmaceutical Company. I'm a doctor of pharmacy, and hold the master degree in biochemistry, and other master in biochemical analysis, and PhD in clinical biochemistry and cancer molecular biology. I'm triple board certified in molecular diagnostics, clinical chemistry, and toxicology. I'm a fellow of the American Academy of Clinical Biochemistry. I'll be speaking today on the potential utility, and the challenges or biomarkers in drug discovery and development.
0:47
On this presentation, I'm going to cover the main topics. Why we need biomarkers in drug development, potential applications of biomarkers in drug discovery and development, and the challenges around that. I will not be able to cover all the challenges, but we'll focus on major ones. We'll provide some insight on possible tools for their mitigations.
1:14
Drug development is a long process, encompasses multiple stages from discovery to final approval. The entire process may take up to 15 years, where from every 5,000 to 10,000 chemical compounds, only about 250 can be good candidates for animal experimentation. Out to this 250, only about five compounds may reach the clinic with a possibility of only one final approved drug. As you can see, rate of success can be only one in 10,000.

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Biomarkers in drug development: potential use and challenges

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