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1. Introduction
2. Roles of calcium ions in physiological processes
3. Ca2+ signaling tool kit
4. EF-hand Ca2+ binding site
5. EF-hand Ca2+ binding proteins
6. Parvalbumin (PV)
7. Calcium-binding sites: calbindin & calretinin (CR)
8. Relevant parameters of Ca2+ buffers
9. Intracellular concentration
10. Details of Ca2+ uncaging in vitro
11. Kinetic parameters of metal binding and release
12. Kinetic properties of calcium buffers
13. Metal-binding affinities
14. Diffusion and interactions with binding partners
15. The role of PV in muscle fibers and neurons
16. PV and contraction-relaxation cycle (1)
17. PV and contraction-relaxation cycle (2)
18. Single twitches vs. tetanic contraction
19. CaBP function study in the cerebellum
20. The role of PV in presynaptic terminals
21. The effect of PV on presynaptic calcium
22. The effect of PV on hippocampal interneurons (1)
23. The effect of PV on hippocampal interneurons (2)
24. The role of CB on calcium signals (1)
25. The role of CB on calcium signals (2)
26. Ca2+ liberation from IP3 and RyRs
27. Calcium buffers effect on calcium waves (1)
28. Calcium buffers effect on calcium waves (2)
29. Calcium buffers effect on calcium waves (3)
30. Calretinin’s complex calcium binding properties
31. Calcium binding scheme for CR
32. Modulation of dendritic calcium signals by CR
33. BAPTA-like physiological calcium buffers
34. Calcium signaling: component absence (1)
35. Calcium signaling: component absence (2)
36. Calcium signaling: component absence (3)
37. Does absence of Ca buffers affect mice behavior?
38. CaBP genotypes & oscillations in mice cerebellum
39. Oscillation effect on motor coordination/learning
40. The Ca2+ homeostasome in Purkinje cells
41. Conclusions
42. Acknowledgments

Topics Covered

• The Ca2+ signaling toolkit
• The EF-hand family of Ca2+-binding proteins
• Biophysical properties of Ca2+ buffers determine their function
• Ca2+ buffers as intracellular Ca2+ signal modulators
• The «slow» buffer parvalbumin (PV) affects fast-twitch muscle function
• Ca2+ buffers modulate short-term plasticity of synaptic transmission
• Phenotypes of Ca2+ buffer knockout mice
• The Ca2+ homeostasome

Links

Series:

• Calcium Signaling I

Categories:

• Biochemistry
• Cell Biology

Talk Citation

Publication History

• Published on September 22, 2013

Financial Disclosures

• Prof. Dr. Beat Schwaller has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.