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- Introduction
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16 min
1. Psychopharmacology: structural aspects of the brain- Prof. Brian Leonard
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66 min
2. The nature of chemical neurotransmission- Prof. Brian Leonard
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28 min
3. Psychotropic drugs- Prof. Brian Leonard
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26 min
4. Psychopharmacology of anxiety disorders- Prof. Brian Leonard
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35 min
5. Psychopharmacology of depression- Prof. Brian Leonard
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48 min
6. Psychopharmacology of mania and schizophrenia- Prof. Brian Leonard
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45 min
7. The role of stress and immune system in psychiatric disorders- Prof. Brian Leonard
- Introduction to Genetic Investigations of Complex Traits
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39 min
- Genetics and Pharmacokinetics of Psychotropic Drugs
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34 min
9. Genetics of phase I enzymes- Prof. Aiming Yu
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36 min
10. Phase II metabolism- Prof. Ann Daly
- Genetics and Pharmacodynamics of Psychotropic Drugs
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25 min
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25 min
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51 min
13. Pharmacogenetics of antidepressants- Prof. Alessandro Serretti
- Clinical Applications of Psychopharmacogenetics
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41 min
14. Of genes and drugs: genetic determinants of adverse drug reactions- Dr. Mario Masellis
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35 min
15. Cocaine and amphetamine addiction genetics- Dr. Gerome Breen
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29 min
- Archived Lectures *These may not cover the latest advances in the field
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47 min
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37 min
18. Genetic determinants of metabolism: clinical applications in psychiatry- Prof. Julia Stingl (formerly Kirchheiner)
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36 min
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47 min
20. Genetic polymorphisms influencing response to lithium- Prof. Alessandro Serretti
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28 min
21. Genetic determinants of antipsychotic-induced weight gain- Prof. Gavin Reynolds
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59 min
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50 min
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37 min
24. Genetic determinants of agranulocytosis- Dr. Michael Dettling
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52 min
25. Genetic polymorphisms influencing the response of antidepressants- Prof. Alessandro Serretti
Printable Handouts
Navigable Slide Index
- Introduction
- How are psychotropic drugs discovered?
- Major breakthroughs
- Expanding the spectrum of psychotropic drugs
- Choice of the model animal
- The main criteria for developing an animal model
- Modeling of disease symptoms (1)
- Modeling of disease symptoms (2)
- Correcting the symptoms in the animal model
- Available models
- In vitro methods of drug development
- In vivo methods of drug development
- Genetically manipulated mice
- Microarray techniques
- Pathway lesions
- Basic mechanisms of action of psychotropic drugs
- Stimulate the release of neurotransmitters
- Block the neurotransmitter receptors
- Increase the synthesis of neurotransmitter
- Manipulate the receptor stimulation
- Inhibit the metabolizing enzyme
- Directly stimulate the neurotransmitter receptors
- Neurotransmitter precursors in diet
- Manipulate the storage vesicles
- Manipulate Ca++ mobilisation
- Other approaches
Topics Covered
- Discovering psychotropic drugs
- Psychotropic drugs: basic mechanisms of action
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Leonard, B. (2007, October 1). Psychotropic drugs [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/SFRC1516.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Brian Leonard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
