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1. Introduction
2. How are psychotropic drugs discovered?
3. Major breakthroughs
4. Expanding the spectrum of psychotropic drugs
5. Choice of the model animal
6. The main criteria for developing an animal model
7. Modeling of disease symptoms (1)
8. Modeling of disease symptoms (2)
9. Correcting the symptoms in the animal model
10. Available models
11. In vitro methods of drug development
12. In vivo methods of drug development
13. Genetically manipulated mice
14. Microarray techniques
15. Pathway lesions
16. Basic mechanisms of action of psychotropic drugs
17. Stimulate the release of neurotransmitters
18. Block the neurotransmitter receptors
19. Increase the synthesis of neurotransmitter
20. Manipulate the receptor stimulation
21. Inhibit the metabolizing enzyme
22. Directly stimulate the neurotransmitter receptors
23. Neurotransmitter precursors in diet
24. Manipulate the storage vesicles
25. Manipulate Ca++ mobilisation
26. Other approaches

Topics Covered

• Discovering psychotropic drugs
• Psychotropic drugs: basic mechanisms of action

Links

Series:

• Psychopharmacogenetics

Categories:

• Neuroscience
• Pharmaceutical Sciences

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Brian Leonard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.